APOE genotype in cerebrovascular disease and vascular dementia

Background: The fact that the allele ε4 of the Apolipoprotein E (APOE) gene could act like a risk factor not only in late-onset familial and sporadic Alzheimer's disease (AD) but also in cerebrovascular disease (CVD) and vascular dementia (VaD) is still controversial. Methods: In order to study...

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Bibliographic Details
Published in:Journal of the neurological sciences 2002-11, Vol.203, p.173-176
Main Authors: Frank, A, Dı́ez-Tejedor, E, Bullido, M.J, Valdivieso, F, Barreiro, P
Format: Article
Language:English
Subjects:
Aged
Alleles
Alzheimer Disease - genetics
Alzheimer Disease - psychology
ApoE
Apolipoproteins E - genetics
Cerebrovascular disease
Cerebrovascular Disorders - genetics
Cerebrovascular Disorders - psychology
Dementia, Vascular - genetics
Dementia, Vascular - psychology
Female
Gene Frequency
Genotype
Humans
Male
Neuropsychological Tests
Psychiatric Status Rating Scales
Vascular dementia
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Summary:Background: The fact that the allele ε4 of the Apolipoprotein E (APOE) gene could act like a risk factor not only in late-onset familial and sporadic Alzheimer's disease (AD) but also in cerebrovascular disease (CVD) and vascular dementia (VaD) is still controversial. Methods: In order to study if ε4 allele is overrepresented not only in AD but also in CVD and VaD, APOE genotyping was undertaken in a series of 247 patients: 26 cases with VaD, 41 cases with CVD but without cognitive impairment (CVD-C), 83 cases with AD and 97 aged-matched “healthy controls” (HC). Results: Percentages of subjects bearing one or two copies of the ε4 allele was much higher in AD patients (54%) than in either CVD-C (29%) ( p
ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(02)00286-1