Application of Interferons in the Control of Infectious Diseases of Cattle

Recovery from infection involves a number of complex interactions between specific cells of the immune system. Many of these interactions are mediated by cytokines, which can activate these cells to kill or reduce the replication rate of the pathogen. Availability of large quantities of recombinant...

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Bibliographic Details
Published in:Journal of dairy science 1991-12, Vol.74 (12), p.4385-4398
Main Authors: Babiuk, L.A., Sordillo, L.M., Campos, M., Hughes, H.P.A., Rossi-Campos, A., Harland, R.
Format: Article
Language:English
Subjects:
Animals
BOVIN LAITIER
bovine respiratory disease
Cattle
Cattle Diseases - prevention & control
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
ENFERMEDADES RESPIRATORIAS
Escherichia coli
Escherichia coli mastitis
FACTEUR IMMUNOLOGIQUE
FACTORES INMUNOLOGICOS
GANADO DE LECHE
IMMUNOSTIMULATION
INMUNOESTIMULACION
INTERFERON
Interferons - therapeutic use
LAIT
LECHE
LEUCOCITOS
LEUCOCYTE
MALADIE RESPIRATOIRE
MAMMITE BOVINE
MASTITIS BOVINA
Mastitis, Bovine - prevention & control
Recombinant Proteins - therapeutic use
REPONSE IMMUNITAIRE
Respiratory Tract Infections - prevention & control
Respiratory Tract Infections - veterinary
RESPUESTA INMUNOLOGICA
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Summary:Recovery from infection involves a number of complex interactions between specific cells of the immune system. Many of these interactions are mediated by cytokines, which can activate these cells to kill or reduce the replication rate of the pathogen. Availability of large quantities of recombinant cytokines has provided the opportunity to investigate the mechanism or mechanisms of action of each cytokine in vitro and in vivo. In the present review, we describe the application of interferons to reduce morbidity and mortality of cattle suffering from bovine respiratory disease and mastitis. The potential application of interferons in disease modulation as well as the impediments to their use are discussed.
ISSN:0022-0302
1525-3198
DOI:10.3168/jds.S0022-0302(91)78635-9