Concomitant Creutzfeldt-Jakob and Alzheimer diseases

We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant pr...

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Bibliographic Details
Published in:Acta neuropathologica 1991-01, Vol.83 (1), p.95-98
Main Authors: Powers, J M, Liu, Y, Hair, L S, Kascsack, R J, Lewis, L D, Levy, L A
Format: Article
Language:English
Subjects:
Aged
Alzheimer Disease - complications
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - pathology
Amyloid beta-Peptides - metabolism
Atrophy - pathology
Blotting, Western
Brain - diagnostic imaging
Brain - pathology
Brain Chemistry
Creutzfeldt-Jakob Syndrome - complications
Creutzfeldt-Jakob Syndrome - diagnostic imaging
Creutzfeldt-Jakob Syndrome - pathology
Female
Humans
Immunoenzyme Techniques
Tomography, X-Ray Computed
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Summary:We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.
ISSN:0001-6322
1432-0533
DOI:10.1007/BF00294437