Long-term monitoring of cell-mediated immunity in disease-free breast cancer patients: a preliminary retrospective study

In 102 N– and 44 N+ disease-free breast cancer patients, lymphocytic populations and skin reaction of delayed hypersensitivity (SRDH) were monitored up to 266 months after mastectomy to find out whether they were similar or different from control values. In two selected groups of 34 N– and 11 N+ bre...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2002-09, Vol.56 (7), p.339-344
Main Authors: Nicolini, A., Carpi, A., Ferrari, P., Tartarelli, G., Anselmi, L., Metelli, M.-R., Gorini, I., Spinelli, C., Miccoli, P., Giardino, R.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Breast cancer
Breast Neoplasms - blood
Breast Neoplasms - immunology
Breast Neoplasms - therapy
Cell-mediated immunity
Disease-free
Disease-Free Survival
Female
Gynecology. Andrology. Obstetrics
Humans
Hypersensitivity, Delayed - immunology
Immunity, Cellular - immunology
Lymphocytes - blood
Mammary gland diseases
Medical sciences
Middle Aged
Monitoring, Immunologic - methods
Retrospective Studies
Tumors
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Summary:In 102 N– and 44 N+ disease-free breast cancer patients, lymphocytic populations and skin reaction of delayed hypersensitivity (SRDH) were monitored up to 266 months after mastectomy to find out whether they were similar or different from control values. In two selected groups of 34 N– and 11 N+ breast cancer patients, the whole 10 year follow-up was divided into three subintervals, each of them lasting 40 months and the time course of lymphocytic populations was evaluated. In the 102 N– patients, mean CD4+, CD8+, CD3+ values were lower ( P 
ISSN:0753-3322
1950-6007
DOI:10.1016/S0753-3322(02)00243-3