Studies on the Synthesis of Sesquiterpene Lactones, 12. Synthesis of (+)-Colartin, (+)-Arbusculin A and Their C-4 Epimers and Their Biological Activities

Colartin [9] and arbusculin A [11] have been synthesized from alpha-santonin [1] in 14.5% (11 steps) and 9.3% (13 steps) overall yields, respectively. Arbusculin A [11] and compounds 20, 21, and 22, which were derived from intermediate 2, showed significant cell growth inhibitory activity against mu...

Full description

Saved in:
Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1991-07, Vol.54 (4), p.1017-1024
Main Authors: Ando, Masayoshi, Isogai, Koji, Azami, Hidenori, Hirata, Naonori, Yanagi, Yoshikazu
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
Animals
ANTINEOPLASTIC AGENTS
Antineoplastic Agents - chemical synthesis
BRASSICA JUNCEA
CELL CULTURE
CELL LINES
CHEMICAL REACTIONS
CRECIMIENTO
CROISSANCE
CUCUMIS SATIVUS
CULTIVO DE CELULAS
CULTURE DE CELLULE
CYTOTOXICITY
ECHINOCHLOA FRUMENTACEA
GROWTH
Isomerism
LACTONAS
LACTONE
LACTONES
LEUCEMIA
LEUCEMIE
LEUKAEMIA
LEUKEMIA
Leukemia P388 - drug therapy
MEDICAMENT CYTOSTATIQUE
Molecular Structure
Plant Growth Regulators - chemical synthesis
PLANT GROWTH SUBSTANCES
PLANTULAS
PLANTULE
REACCIONES QUIMICAS
REACTION CHIMIQUE
SEEDLINGS
Sesquiterpenes - chemical synthesis
Sesquiterpenes - pharmacology
SESQUITERPENOID LACTONES
SESQUITERPENOIDE
SESQUITERPENOIDS
SESQUITERPENOS
SUBSTANCE DE CROISSANCE VEGETALE
SUSTANCIAS DE CRECIMIENTO VEGETAL
TOXICIDAD
TOXICITE
TOXICITY
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Colartin [9] and arbusculin A [11] have been synthesized from alpha-santonin [1] in 14.5% (11 steps) and 9.3% (13 steps) overall yields, respectively. Arbusculin A [11] and compounds 20, 21, and 22, which were derived from intermediate 2, showed significant cell growth inhibitory activity against murine lymphocytic leukemia (P-388) in vitro. Plant growth regulating activity of 11 and its synthetic intermediates 4, 5, 8, and 9 was also studied.
ISSN:0163-3864
1520-6025
DOI:10.1021/np50076a015