Immunoglobulin Genes: Generating Diversity with AID and UNG

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody...

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Bibliographic Details
Published in:Current biology 2002-10, Vol.12 (21), p.R725-R727
Main Authors: Storb, Ursula, Stavnezer, Janet
Format: Article
Language:English
Subjects:
Animals
Cytidine Deaminase - metabolism
DNA Glycosylases
Genes, Immunoglobulin
Mice
N-Glycosyl Hydrolases - metabolism
Uracil-DNA Glycosidase
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Summary:Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
ISSN:0960-9822
1879-0445
DOI:10.1016/S0960-9822(02)01247-2