Role of the midline glia and neurons in the formation of the axon commissures in the central nervous system of the Drosophila embryo

A row of midline precursor cells separates the two lateral neurogenic regions that give rise to most of the Drosophila CNS. From these midline precursors arises a discrete set of special glia and neurons. The growth cones of many CNS neurons initially head straight towards the midline and change the...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1991, Vol.633 (1), p.142-159
Main Authors: Klambt C, Goodman C.S
Format: Article
Language:English
Subjects:
animal tissues
Animals
Axons - physiology
biologia
biologie
biology
Cell Line
Cell Movement
central nervous system
Central Nervous System - cytology
Central Nervous System - embryology
drosophila
Drosophila - embryology
Drosophila - genetics
genetica molecular
genetique moleculaire
Models, Neurological
molecular genetics
Mutation
nerf
nerves
nervios
Neuroglia - physiology
Neurons - physiology
sistema nervioso central
Stem Cells - physiology
systeme nerveux central
tejidos animales
tissu animal
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Summary:A row of midline precursor cells separates the two lateral neurogenic regions that give rise to most of the Drosophila CNS. From these midline precursors arises a discrete set of special glia and neurons. The growth cones of many CNS neurons initially head straight towards the midline and change their behavior after traversing it, leading to the hypothesis that these midline cells play a key role in the formation of the axon commissures. We have used a variety of cellular and molecular genetic techniques to elucidate the cells and interactions, including specific cell migrations, that are important for the normal formation of the two major commissures in each segment. This cellular analysis has led to a model that proposes a series of sequential cell interactions controlling the three stages in commissure development: (1) formation of the posterior commissure, (2) formation of the anterior commissure, and (3) separation of the two commissures. An initial genetic test of this model has used a number of mutations that, by either eliminating or altering the differentiation of various midline cells, perturb the development of the axon commissures in a predictable manner.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1991.tb15604.x