Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus

• Published in: American journal of physiology: endocrinology and metabolism 2002-12, Vol.283 (6), p.E1135-E1143
• Main Authors: Miyazaki, Yoshinori, Glass, Leonard, Triplitt, Curtis, Wajcberg, Estela, Mandarino, Lawrence J, DeFronzo, Ralph A
• Format: Article
• Language: English
• Subjects: Abdomen; Adipose Tissue - metabolism; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2 - metabolism; Female; Glucose - metabolism; Glucose Clamp Technique; Humans; Insulin - pharmacology; Insulin Resistance - physiology; Liver - drug effects; Liver - metabolism; Magnetic Resonance Imaging; Male; Middle Aged; Sex Factors
• ISSN: 0193-1849; 1522-1555
• DOI: 10.1152/ajpendo.0327.2001

University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, Texas 78229-3900 We examined the relationship between peripheral/hepatic insulin sensitivity and abdominal superficial/deep subcutaneous fat (SSF/DSF) and intra-abdominal visceral fat (VF) in patients with type 2 diabetes mellitus (T2DM). Sixty-two T2DM patients (36 males and 26 females, age = 55 ± 3 yr, body mass index = 30 ± 1 kg/m 2 ) underwent a two-step euglycemic insulin clamp (40 and 160 mU · m 2 · min 1 ) with [3- 3 H]glucose. SSF, DSF, and VF areas were quantitated with magnetic resonance imaging at the L 4-5 level. Basal endogenous glucose production (EGP), hepatic insulin resistance index (basal EGP   × FPI), and total glucose disposal (TGD) during the first and second insulin clamp steps were similar in male and female subjects. VF (159 ± 9 vs. 143 ± 9 cm 2 ) and DSF (199 ± 14 vs. 200 ± 15 cm 2 ) were not different in male and female subjects. SSF (104 ± 8   vs. 223 ± 15 cm 2 ) was greater ( P