Rapid Synthesis of a Glycosylphosphatidylinositol-Based Malaria Vaccine Using Automated Solid-Phase Oligosaccharide Synthesis

Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, co...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2002-11, Vol.124 (45), p.13434-13436
Main Authors: Hewitt, Michael C, Snyder, Daniel A, Seeberger, Peter H
Format: Article
Language:English
Subjects:
Applied microbiology
Biological and medical sciences
Carbohydrate Sequence
Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Glycosylphosphatidylinositols - chemical synthesis
Malaria Vaccines - chemical synthesis
Microbiology
Molecular Sequence Data
Oligosaccharides - chemical synthesis
Organic chemistry
Preparations and properties
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja027538k