Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria

Human FcgammaRIIA and FcgammaRIIIB exhibit genetic polymorphisms, FcgammaRIIA-131H/R and FcgammaRIIIB-NA1/NA2, coding for different capacities for IgG binding and phagocytosis. Recently, FcgammaRIIA-131R was reported to be associated with protection against high-density Plasmodium falciparum infecti...

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Bibliographic Details
Published in:Parasitology international 2002-12, Vol.51 (4), p.361-366
Main Authors: Omi, Kazuya, Ohashi, Jun, Patarapotikul, Jintana, Hananantachai, Hathairad, Naka, Izumi, Looareesuwan, Sornchai, Tokunaga, Katsushi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antigens, CD - genetics
Gene Frequency
Genetic Predisposition to Disease
GPI-Linked Proteins
Haplotypes - genetics
Humans
Malaria, Cerebral - genetics
Malaria, Cerebral - immunology
Polymorphism, Genetic
Receptors, IgG - genetics
Thailand
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Summary:Human FcgammaRIIA and FcgammaRIIIB exhibit genetic polymorphisms, FcgammaRIIA-131H/R and FcgammaRIIIB-NA1/NA2, coding for different capacities for IgG binding and phagocytosis. Recently, FcgammaRIIA-131R was reported to be associated with protection against high-density Plasmodium falciparum infection in Kenya. Furthermore, FcgammaRIIIB-NA1/NA2 polymorphism was shown to influence FcgammaRIIA function in an allele-specific manner. In this study, we examined a possible association of FcgammaRIIA-131H/R and FcgammaRIIIB-NA1/NA2 polymorphisms with malaria severity in 107 cerebral malaria patients, 157 non-cerebral severe malaria patients, and 202 mild malaria controls living in northwest Thailand. This study reveals that, with the FcgammaRIIIB-NA2 allele, the FcgammaRIIA-131H/H genotype is associated with susceptibility to cerebral malaria (OR 1.85, 95% CI 1.14-3.01; P=0.012), although these polymorphisms are not individually involved in the disease severity. Our results suggest that FcgammaRIIA-131H/R and FcgammaRIIIB-NA1/NA2 polymorphisms have an interactive effect on host defense against malaria infection.
ISSN:1383-5769