Relative oral bioavailability of microgranulated amoxicillin in pigs

A new microgranulated formulation of amoxicillin trihydrate for in-feed medication was developed using a lipogelled matrix. Its relative bioavailability was compared with powdered drug in pigs and an assessment was made to determine whether therapeutic concentrations were achieved. Microgranules con...

Full description

Saved in:
Bibliographic Details
Published in:Journal of veterinary pharmacology and therapeutics 2002-10, Vol.25 (5), p.329-334
Main Authors: Anfossi, P, Zaghini, A, Grassigli, G, Menotta, S, Fedrizzi, G
Format: Article
Language:English
Subjects:
Administration, Oral
amoxicillin
Amoxicillin - administration & dosage
Amoxicillin - blood
Amoxicillin - pharmacokinetics
Animals
Area Under Curve
bioavailability
Biological Availability
Chemistry, Pharmaceutical
Chromatography, High Pressure Liquid - veterinary
Cross-Over Studies
drug formulations
Female
fish
high performance liquid chromatography
Male
Penicillins - administration & dosage
Penicillins - blood
Penicillins - pharmacokinetics
Random Allocation
swine
Swine - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new microgranulated formulation of amoxicillin trihydrate for in-feed medication was developed using a lipogelled matrix. Its relative bioavailability was compared with powdered drug in pigs and an assessment was made to determine whether therapeutic concentrations were achieved. Microgranules containing 10% (MICR10) and 30% (MICR30) amoxicillin and free amoxicillin trihydrate powder (reference, AMX) were administered at dosages of 50 mg of amoxicillin/kg b.w. using a three-way-crossover design. Amoxicillin analysis in serum was performed by a sensitive high performance liquid chromatography (HPLC) method with fluorometric detection, using an extraction procedure already described for edible tissues of fish and adapted and validated for pig serum. The oral bioavailability of both microgranulated formulations was higher than that of the reference formulation [relative bioavailability (F): 153.9 ± 58.2% for MICR10; 126.2 ± 70.5% for MICR30] and the area under the concentration–time curve (AUC) values of MICR10 and AMX formulations were significantly different (P < 0.05). Differences between the mean maximum concentration (C(max)), time of C(max) (t(max)) and mean residence time (MRT) of the drug formulations were not significant. Microgranulated amoxicillin is suitable for in-feed administration to pigs and, because of its higher oral bioavailability compared with the powdered compound, it may be more effective for the treatment of susceptible infections.
ISSN:0140-7783
1365-2885
DOI:10.1046/j.1365-2885.2002.00428.x