Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study

This study documents expression of dopamine (DA) receptors on leukocyte subpopulations using flow cytometric techniques to identify dopamine receptors with subtype-specific antibodies. Of the D1-like receptor family (D 1 and D 5), only D 5 was detected, and of the D2-like receptor family (D 2, D 3 a...

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Bibliographic Details
Published in:Journal of neuroimmunology 2002-11, Vol.132 (1), p.34-40
Main Authors: McKenna, F, McLaughlin, P.J, Lewis, B.J, Sibbring, G.C, Cummerson, J.A, Bowen-Jones, D, Moots, R.J
Format: Article
Language:English
Subjects:
B-Lymphocytes - chemistry
Dopamine receptor
Eosinophils - chemistry
Flow Cytometry
Human leukocytes
Humans
Killer Cells, Natural - chemistry
Monocytes - chemistry
Neuroimmunology
Neutrophils - chemistry
Receptors, Dopamine - analysis
T-Lymphocytes - chemistry
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Summary:This study documents expression of dopamine (DA) receptors on leukocyte subpopulations using flow cytometric techniques to identify dopamine receptors with subtype-specific antibodies. Of the D1-like receptor family (D 1 and D 5), only D 5 was detected, and of the D2-like receptor family (D 2, D 3 and D 4), all dopamine receptors were detected. T-lymphocytes and monocytes had low expression of dopamine receptors, whereas neutrophils and eosinophils had moderate expression. B cells and NK cells had higher and more consistent expression. Dopamine receptors D 3 and D 5 were found in most individuals whereas D 2 and D 4 had more variable expression. D 1 was never found.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(02)00280-1