The Tol proteins of Escherichia coli and their involvement in the translocation of group A colicins

The Tol proteins are involved in outer membrane stability of Gram-negative bacteria. The TolQRA proteins form a complex in the inner membrane while TolB and Pal interact near the outer membrane. These two complexes are transiently connected by an energy-dependent interaction between Pal and TolA. Th...

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Bibliographic Details
Published in:Biochimie 2002-05, Vol.84 (5), p.391-397
Main Authors: Lazzaroni, Jean-Claude, Dubuisson, Jean-François, Vianney, Anne
Format: Article
Language:English
Subjects:
Colicins - metabolism
Energy transduction
Escherichia coli
Escherichia coli - metabolism
Escherichia coli Proteins - metabolism
Group A colicins
Membrane Proteins - metabolism
Protein Transport - physiology
Signal transduction
Tol–Pal proteins
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Summary:The Tol proteins are involved in outer membrane stability of Gram-negative bacteria. The TolQRA proteins form a complex in the inner membrane while TolB and Pal interact near the outer membrane. These two complexes are transiently connected by an energy-dependent interaction between Pal and TolA. The Tol proteins have been parasitized by group A colicins for their translocation through the cell envelope. Recent advances in the structure and energetics of the Tol system, as well as the interactions between the N-terminal translocation domain of colicins and the Tol proteins are presented.
ISSN:0300-9084
1638-6183
DOI:10.1016/S0300-9084(02)01419-0