Loading…

Late hemodynamic changes following controlled hemorrhage and volume restitution with blood or Haemaccel in anesthetized portal hypertensive rats

Background and Aim : In portal hypertensive rats, hemorrhage and acute volume restitution with Haemaccel induced increased cardiac output and portal venous inflow. In the present study, the late hemodynamic effects of this procedure were explored. Methods : Portal hypertension was induced by portal...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2002-12, Vol.17 (12), p.1317-1322
Main Authors: HILZENRAT, NIR, YAARI, ARIEH, SIKULER, EMANUEL
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and Aim : In portal hypertensive rats, hemorrhage and acute volume restitution with Haemaccel induced increased cardiac output and portal venous inflow. In the present study, the late hemodynamic effects of this procedure were explored. Methods : Portal hypertension was induced by portal vein constriction. Blood was withdrawn 11.2 ± 3.2 days later, at a rate of 0.3 mL/min, for 15 min, followed by 15 min of stabilization. Haemaccel or blood were infused at the same rate and volume used for withdrawal. Hemodynamic measurements were performed after 24 h, using radioactive microspheres. Viscosity was measured with an Ostwald viscometer. Vascular hindrance was calculated as resistance/viscosity ratio. Results : Blood viscosity of the Haemaccel group (n = 11), was lower than in the blood group (n = 11): 2.7 ± 0.2 versus 4.0 ± 0.4 (P < 0.01). Arterial pressure, cardiac output, peripheral resistance, portal pressure, portal venous inflow and splanchnic arteriolar resistance were not significantly different. Splanchnic arteriolar and portocollateral hindrance were higher in the Haemaccel group (11.7 ± 5.3 and 1.5 ± 0.6 vs 7.7 ± 3.0 and 0.9 ± 0.4 mmHg × min × 100 gram body weight/mL, respectively, P < 0.05). Conclusion : In portal hypertensive rats, vital organs perfusion, 24 h after hemorrhage and isovolemic volume restitution with Haemaccel and blood, was similar. However, in Haemaccel‐transfused animals, a reduction in vascular hindrance, indicating vasoconstriction, was observed in the splanchnic organs, which drain into the portal circulation. Vasoconstriction of the portocollateral vascular bed was observed as well. We suggest that slow‐rate volume replacement during a portal‐hypertensive‐related bleeding episode enables hemodynamic adaptation to occur. Thus, undesirable hyperdynamic changes, which may aggravate secondary bleeding, are attenuated. © 2002 Blackwell Publishing Asia Pty Ltd
ISSN:0815-9319
1440-1746
DOI:10.1046/j.1440-1746.2002.02886.x