Detection of a Novel Pattern of Connexin 43 Immunoreactivity Responsive to Dehydration in Rat Hypothalamic Magnocellular Nuclei

Immunocytochemical expression of Connexin 43 (Cx 43) in the rat Supraoptic Nucleus was analyzed following dehydration, using sequence-specific anti-Cx 43 antibodies (designated 13-8300, 71-0700, and sc-9059) that exhibit differential recognition of Cx 43. Punctate and longitudinally arranged immunos...

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Bibliographic Details
Published in:Experimental neurology 2002-09, Vol.177 (1), p.321-325
Main Authors: Eisner, Ines, Colombo, Jorge A.
Format: Article
Language:English
Subjects:
Animals
astroglia
Biological and medical sciences
cell coupling
connexin 43
Connexin 43 - analysis
Connexin 43 - biosynthesis
Connexin 43 - immunology
Dehydration - immunology
Dehydration - metabolism
Diseases of striated muscles. Neuromuscular diseases
Female
gap junctions
Immunohistochemistry
Lactation - physiology
Male
Medical sciences
neural plasticity
Neurology
Rats
Rats, Sprague-Dawley
supraoptic nucleus
Supraoptic Nucleus - chemistry
Supraoptic Nucleus - metabolism
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Summary:Immunocytochemical expression of Connexin 43 (Cx 43) in the rat Supraoptic Nucleus was analyzed following dehydration, using sequence-specific anti-Cx 43 antibodies (designated 13-8300, 71-0700, and sc-9059) that exhibit differential recognition of Cx 43. Punctate and longitudinally arranged immunostaining patterns of Cx 43 labeling, as evidenced by antibody sc-9059, was detected overlaying the nucleus of magnocellular neuroendocrine cells. This novel form of longitudinally arranged Cx 43 immunoreactivity was modified by dehydration and halothane exposure, but not lactation.
ISSN:0014-4886
1090-2430
DOI:10.1006/exnr.2002.7953