New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae

• Published in: Planta 2002-11, Vol.216 (1), p.162-167
• Main Authors: Pullen, Christian, Schmitz, Petra, Meurer, Kristina, v. Bamberg, Daniel D., Lohmann, Stephanie, De Castro França, Suzelei, Groth, Ingrid, Schlegel, Brigitte, Möllmann, Ute, Gollmick, Friedrich, Gräfe, Udo, Leistner, Eckhard
• Format: Article
• Language: English
• Subjects: Actinomycetes; Animal and plant ecology; Animal, plant and microbial ecology; Antibiotics; Antibiotics, Antineoplastic - pharmacology; Autoecology; Bacteria; Bacteria - drug effects; Bioactive compounds; Biological and medical sciences; Biological Factors - chemistry; Biological Factors - isolation & purification; Biological Factors - pharmacology; Celastraceae; Celastraceae - metabolism; Celastraceae - microbiology; Endophytes; Endosymbionts; Fundamental and applied biological sciences. Psychology; General pharmacology; Habitat; Magnetic Resonance Spectroscopy; Mass spectroscopy; Maytenus; Maytenus - metabolism; Maytenus - microbiology; Medical sciences; Molecular spectra; Naphthoquinones - chemistry; Naphthoquinones - isolation & purification; Naphthoquinones - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants; Plants and fungi; Protons; Pyrroles - chemistry; Pyrroles - isolation & purification; Pyrroles - pharmacology; Resorcinols - chemistry; Resorcinols - isolation & purification; Resorcinols - pharmacology; Ribosomal DNA; Streptomyces; Streptomyces - growth & development; Streptomyces - metabolism
• ISSN: 0032-0935; 1432-2048
• DOI: 10.1007/s00425-002-0874-6

Wood from three different plants of the Celastraceae growing in their natural habitats in Brazil (Maytenus aquifolia Mart.) and South Africa [Putterlickia retrospinosa van Wyk and Mostert, P. verrucosa (E. Meyer ex Sonder) Szyszyl.] was established as a source of endophytic bacteria using a medium selective for actinomycetes. Two isolates were identified as Streptomyces setonii and S. sampsonii whereas two others were not assignable to any of the known Streptomyces species. They were preliminarily named Streptomyces Q21 and Streptomyces MaB-QuH-8. The latter strain produces a new chloropyrrol and chlorinated anthracyclinone. The chloropyrrol showed high activity against a series of multiresistent bacteria and mycobacteria.