In situ light dosimetry during photodynamic therapy of Barrett's esophagus with 5-aminolevulinic acid

• Published in: Lasers in surgery and medicine 2002-01, Vol.31 (5), p.299-304
• Main Authors: van Veen, Robert L.P., Aalders, Maurice C.G., Pasma, Kasper L., Siersema, Peter D., Haringsma, Jelle, van de Vrie, Wim, Gabeler, Edward E.E., Robinson, Dominic J., Sterenborg, Henricus J.C.M.
• Format: Article
• Language: English
• Subjects: Aminolevulinic Acid - therapeutic use; back scattering; Barrett Esophagus - drug therapy; Biological and medical sciences; Diseases of the digestive system; Esophagus; Esophagus - radiation effects; fluence; fluence rate; Gastroenterology. Liver. Pancreas. Abdomen; Humans; isotropic detectors; Light; Medical sciences; Other diseases. Semiology; Photochemotherapy; Photosensitizing Agents - therapeutic use; Pilot Projects; Prospective Studies; Radiometry; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Reproducibility of Results; Scattering, Radiation; Time Factors
• ISSN: 0196-8092; 1096-9101
• DOI: 10.1002/lsm.10129

Background and Objectives Previous studies with PhotoDynamic Therapy (PDT) in bladder and bronchi have shown that due to scattering and reflection, the actually delivered fluence rate on the surface in a hollow organ can be significantly higher than expected. In this pilot study, we investigated the differences between the primary calculated and the actual measured fluence rate during PDT of Barrett's Esophagus (BE) using 23 independent clinical measurements in 15 patients. Study Design/Materials and Methods A KTP‐dye module laser at 630 nm was used as light source. Light delivery was performed using a cylindrical light diffuser inserted in the center of an inflatable transparent balloon with a length corresponding to the length of the Barrett's epithelium. The total light output power of the cylindrical diffuser was calibrated using an integrating sphere to deliver a primary fluence rate of 100 mW cm−2. Two fiber‐optic pseudo sphere isotropic detectors were placed on the balloon and were used to measure fluence rate at the surface of the esophageal wall during PDT. Results and Conclusions The actual fluence rate measured was 1.5–3.9 times higher than the primary fluence rate for 630 nm. In general, the fluence rate amplification factor decreased with increasing redness of the tissue and was less for shorter diffusers. Fluence rate variations in time were observed which coincided with patients coughing, movement, and esophageal spasms. These factors combined with inter patient variability of the fluence rate measured appears to justify the routine application of this technique in PDT of BE. Lasers Surg. Med. 31:299–304, 2002. © 2002 Wiley‐Liss, Inc.