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Alcohol Consumption and Incidence of Benign Breast Disease
We evaluated whether moderate alcohol consumption is associated with increased risk of developing benign breast disease (BBD), a potential “precursor” or marker for breast cancer development. This study evaluated associations between reported alcohol consumption and BBD diagnosis among 75,826 women...
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| Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2002-11, Vol.11 (11), p.1369-1374 |
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| container_end_page | 1374 |
| container_issue | 11 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
| container_volume | 11 |
| creator | BYRNE, Celia WEBB, Penelope M JACOBS, Timothy W PEIRO, Gloria SCHNITT, Stuart J CONNOLLY, James L WILLETT, Walter C COLDITZ, Graham A |
| description | We evaluated whether moderate alcohol consumption is associated with increased risk of developing benign breast disease (BBD),
a potential “precursor” or marker for breast cancer development. This study evaluated associations between reported alcohol
consumption and BBD diagnosis among 75,826 women in the Nurses’ Health Study II. Between 1989 and 1997, 16,035 women reported
a first diagnosis of BBD (317/10,000 person-years), of which 2,999 diagnoses were confirmed by tissue biopsy (59/10,000 person-years).
Of the pathology specimens reviewed, 532 were nonproliferative benign breast conditions, and 932 were proliferative conditions.
Person-time models provided estimates of the rate ratio (RR) and 95% confidence interval (CI). Reported recent adult consumption
of alcohol was not associated with increased BBD incidence. Compared with women who did not drink alcohol, the age- and body
mass index (BMI)-adjusted RRs for any reported BBD were 0.98 (95% CI, 0.95–1.02) for those who consumed |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_72678308</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72678308</sourcerecordid><originalsourceid>FETCH-LOGICAL-h271t-ebce5fbacc39f5bf95c78b207a0bb8cd3656bb161e749de4df91b4401584afb23</originalsourceid><addsrcrecordid>eNpFz11LwzAUBuAiipvTvyC9UfCikM-m8W6bX4OBN3pdkvRkjbTpTFrEf29wE-HAey4eXnhPsjnmtCqE4Pw0_YjzQsqSz7KLGD8QQkJyfp7NMGGUCkzn2f2yM0M7dPl68HHq96MbfK58k2-8cQ14A_lg8xV4t_P5KoCKY_7gYkq4zM6s6iJcHXORvT89vq1fiu3r82a93BYtEXgsQBvgVitjqLRcW8mNqDRBQiGtK9PQkpda4xKDYLIB1liJNWMI84opqwldZLeH3n0YPieIY927aKDrlIdhirUgpagoqhK8PsJJ99DU--B6Fb7rv7UJ3ByBikZ1Nqg0Mv47hgjFhCd3d3Ct27VfLkBtkoQQIA0Ppq0x_j1aSvoDucBscw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72678308</pqid></control><display><type>article</type><title>Alcohol Consumption and Incidence of Benign Breast Disease</title><source>EZB Electronic Journals Library</source><creator>BYRNE, Celia ; WEBB, Penelope M ; JACOBS, Timothy W ; PEIRO, Gloria ; SCHNITT, Stuart J ; CONNOLLY, James L ; WILLETT, Walter C ; COLDITZ, Graham A</creator><creatorcontrib>BYRNE, Celia ; WEBB, Penelope M ; JACOBS, Timothy W ; PEIRO, Gloria ; SCHNITT, Stuart J ; CONNOLLY, James L ; WILLETT, Walter C ; COLDITZ, Graham A</creatorcontrib><description>We evaluated whether moderate alcohol consumption is associated with increased risk of developing benign breast disease (BBD),
a potential “precursor” or marker for breast cancer development. This study evaluated associations between reported alcohol
consumption and BBD diagnosis among 75,826 women in the Nurses’ Health Study II. Between 1989 and 1997, 16,035 women reported
a first diagnosis of BBD (317/10,000 person-years), of which 2,999 diagnoses were confirmed by tissue biopsy (59/10,000 person-years).
Of the pathology specimens reviewed, 532 were nonproliferative benign breast conditions, and 932 were proliferative conditions.
Person-time models provided estimates of the rate ratio (RR) and 95% confidence interval (CI). Reported recent adult consumption
of alcohol was not associated with increased BBD incidence. Compared with women who did not drink alcohol, the age- and body
mass index (BMI)-adjusted RRs for any reported BBD were 0.98 (95% CI, 0.95–1.02) for those who consumed <5 g/day, 0.93 (95%
CI, 0.89–0.98) for those who consumed 5–14.9 g/day, and 0.90 (95% CI, 0.83–0.98) for those who consumed ≥15 g/day. The adjusted
RRs for biopsy confirmed BBD and any proliferative benign condition were similiar. However, reported alcohol consumption of
≥15 g/day between ages 18 and 22 years was associated with higher rates of biopsy-confirmed BBD (age- and body mass index-adjusted
RR = 1.14; 95% CI, 1.00–1.30), nonproliferative BBD (RR = 1.46; 95% CI, 1.09–1.96), and any proliferative BBD (RR = 1.33;
95% CI, 1.05–1.69), but not atypical hyperplasia. In this study, recent alcohol consumption was associated with slightly lower
rates of reported BBD. However, greater alcohol consumption earlier in life (ages 18–22 years) was associated with higher
proliferative BBD rates, suggesting that timing of exposure may be relevant to disease incidence.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 12433713</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Alcohol Drinking - adverse effects ; Biological and medical sciences ; Biopsy ; Body Mass Index ; Breast - pathology ; Breast Diseases - diagnosis ; Breast Diseases - epidemiology ; Breast Diseases - etiology ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Breast Neoplasms - pathology ; Cohort Studies ; Female ; Follow-Up Studies ; Gynecology. Andrology. Obstetrics ; Humans ; Incidence ; Mammary gland diseases ; Medical sciences ; Menopause ; Neoplasms - epidemiology ; Neoplasms - etiology ; Neoplasms - pathology ; Prospective Studies ; Risk Factors ; Smoking ; Surveys and Questionnaires ; Tumors ; Women's Health</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2002-11, Vol.11 (11), p.1369-1374</ispartof><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14023125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12433713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BYRNE, Celia</creatorcontrib><creatorcontrib>WEBB, Penelope M</creatorcontrib><creatorcontrib>JACOBS, Timothy W</creatorcontrib><creatorcontrib>PEIRO, Gloria</creatorcontrib><creatorcontrib>SCHNITT, Stuart J</creatorcontrib><creatorcontrib>CONNOLLY, James L</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><title>Alcohol Consumption and Incidence of Benign Breast Disease</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>We evaluated whether moderate alcohol consumption is associated with increased risk of developing benign breast disease (BBD),
a potential “precursor” or marker for breast cancer development. This study evaluated associations between reported alcohol
consumption and BBD diagnosis among 75,826 women in the Nurses’ Health Study II. Between 1989 and 1997, 16,035 women reported
a first diagnosis of BBD (317/10,000 person-years), of which 2,999 diagnoses were confirmed by tissue biopsy (59/10,000 person-years).
Of the pathology specimens reviewed, 532 were nonproliferative benign breast conditions, and 932 were proliferative conditions.
Person-time models provided estimates of the rate ratio (RR) and 95% confidence interval (CI). Reported recent adult consumption
of alcohol was not associated with increased BBD incidence. Compared with women who did not drink alcohol, the age- and body
mass index (BMI)-adjusted RRs for any reported BBD were 0.98 (95% CI, 0.95–1.02) for those who consumed <5 g/day, 0.93 (95%
CI, 0.89–0.98) for those who consumed 5–14.9 g/day, and 0.90 (95% CI, 0.83–0.98) for those who consumed ≥15 g/day. The adjusted
RRs for biopsy confirmed BBD and any proliferative benign condition were similiar. However, reported alcohol consumption of
≥15 g/day between ages 18 and 22 years was associated with higher rates of biopsy-confirmed BBD (age- and body mass index-adjusted
RR = 1.14; 95% CI, 1.00–1.30), nonproliferative BBD (RR = 1.46; 95% CI, 1.09–1.96), and any proliferative BBD (RR = 1.33;
95% CI, 1.05–1.69), but not atypical hyperplasia. In this study, recent alcohol consumption was associated with slightly lower
rates of reported BBD. However, greater alcohol consumption earlier in life (ages 18–22 years) was associated with higher
proliferative BBD rates, suggesting that timing of exposure may be relevant to disease incidence.</description><subject>Adult</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Body Mass Index</subject><subject>Breast - pathology</subject><subject>Breast Diseases - diagnosis</subject><subject>Breast Diseases - epidemiology</subject><subject>Breast Diseases - etiology</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Incidence</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - pathology</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><subject>Women's Health</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpFz11LwzAUBuAiipvTvyC9UfCikM-m8W6bX4OBN3pdkvRkjbTpTFrEf29wE-HAey4eXnhPsjnmtCqE4Pw0_YjzQsqSz7KLGD8QQkJyfp7NMGGUCkzn2f2yM0M7dPl68HHq96MbfK58k2-8cQ14A_lg8xV4t_P5KoCKY_7gYkq4zM6s6iJcHXORvT89vq1fiu3r82a93BYtEXgsQBvgVitjqLRcW8mNqDRBQiGtK9PQkpda4xKDYLIB1liJNWMI84opqwldZLeH3n0YPieIY927aKDrlIdhirUgpagoqhK8PsJJ99DU--B6Fb7rv7UJ3ByBikZ1Nqg0Mv47hgjFhCd3d3Ct27VfLkBtkoQQIA0Ppq0x_j1aSvoDucBscw</recordid><startdate>20021101</startdate><enddate>20021101</enddate><creator>BYRNE, Celia</creator><creator>WEBB, Penelope M</creator><creator>JACOBS, Timothy W</creator><creator>PEIRO, Gloria</creator><creator>SCHNITT, Stuart J</creator><creator>CONNOLLY, James L</creator><creator>WILLETT, Walter C</creator><creator>COLDITZ, Graham A</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20021101</creationdate><title>Alcohol Consumption and Incidence of Benign Breast Disease</title><author>BYRNE, Celia ; WEBB, Penelope M ; JACOBS, Timothy W ; PEIRO, Gloria ; SCHNITT, Stuart J ; CONNOLLY, James L ; WILLETT, Walter C ; COLDITZ, Graham A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h271t-ebce5fbacc39f5bf95c78b207a0bb8cd3656bb161e749de4df91b4401584afb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Body Mass Index</topic><topic>Breast - pathology</topic><topic>Breast Diseases - diagnosis</topic><topic>Breast Diseases - epidemiology</topic><topic>Breast Diseases - etiology</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Incidence</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - etiology</topic><topic>Neoplasms - pathology</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BYRNE, Celia</creatorcontrib><creatorcontrib>WEBB, Penelope M</creatorcontrib><creatorcontrib>JACOBS, Timothy W</creatorcontrib><creatorcontrib>PEIRO, Gloria</creatorcontrib><creatorcontrib>SCHNITT, Stuart J</creatorcontrib><creatorcontrib>CONNOLLY, James L</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><creatorcontrib>COLDITZ, Graham A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BYRNE, Celia</au><au>WEBB, Penelope M</au><au>JACOBS, Timothy W</au><au>PEIRO, Gloria</au><au>SCHNITT, Stuart J</au><au>CONNOLLY, James L</au><au>WILLETT, Walter C</au><au>COLDITZ, Graham A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol Consumption and Incidence of Benign Breast Disease</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2002-11-01</date><risdate>2002</risdate><volume>11</volume><issue>11</issue><spage>1369</spage><epage>1374</epage><pages>1369-1374</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>We evaluated whether moderate alcohol consumption is associated with increased risk of developing benign breast disease (BBD),
a potential “precursor” or marker for breast cancer development. This study evaluated associations between reported alcohol
consumption and BBD diagnosis among 75,826 women in the Nurses’ Health Study II. Between 1989 and 1997, 16,035 women reported
a first diagnosis of BBD (317/10,000 person-years), of which 2,999 diagnoses were confirmed by tissue biopsy (59/10,000 person-years).
Of the pathology specimens reviewed, 532 were nonproliferative benign breast conditions, and 932 were proliferative conditions.
Person-time models provided estimates of the rate ratio (RR) and 95% confidence interval (CI). Reported recent adult consumption
of alcohol was not associated with increased BBD incidence. Compared with women who did not drink alcohol, the age- and body
mass index (BMI)-adjusted RRs for any reported BBD were 0.98 (95% CI, 0.95–1.02) for those who consumed <5 g/day, 0.93 (95%
CI, 0.89–0.98) for those who consumed 5–14.9 g/day, and 0.90 (95% CI, 0.83–0.98) for those who consumed ≥15 g/day. The adjusted
RRs for biopsy confirmed BBD and any proliferative benign condition were similiar. However, reported alcohol consumption of
≥15 g/day between ages 18 and 22 years was associated with higher rates of biopsy-confirmed BBD (age- and body mass index-adjusted
RR = 1.14; 95% CI, 1.00–1.30), nonproliferative BBD (RR = 1.46; 95% CI, 1.09–1.96), and any proliferative BBD (RR = 1.33;
95% CI, 1.05–1.69), but not atypical hyperplasia. In this study, recent alcohol consumption was associated with slightly lower
rates of reported BBD. However, greater alcohol consumption earlier in life (ages 18–22 years) was associated with higher
proliferative BBD rates, suggesting that timing of exposure may be relevant to disease incidence.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>12433713</pmid><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 2002-11, Vol.11 (11), p.1369-1374 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Adult Alcohol Drinking - adverse effects Biological and medical sciences Biopsy Body Mass Index Breast - pathology Breast Diseases - diagnosis Breast Diseases - epidemiology Breast Diseases - etiology Breast Neoplasms - epidemiology Breast Neoplasms - etiology Breast Neoplasms - pathology Cohort Studies Female Follow-Up Studies Gynecology. Andrology. Obstetrics Humans Incidence Mammary gland diseases Medical sciences Menopause Neoplasms - epidemiology Neoplasms - etiology Neoplasms - pathology Prospective Studies Risk Factors Smoking Surveys and Questionnaires Tumors Women's Health |
| title | Alcohol Consumption and Incidence of Benign Breast Disease |
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