Chromaffin Cells as Models of Endocrine Cells and Neurons

: Chromaffin cells have many functional similarities to amine‐ and peptide‐producing endocrine cells throughout the body and to both peripheral and central neurons. The hypothesis of a shared, neural origin for chromaffin cells and most other endocrine cells is not tenable. However, chromaffin cells...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2002-10, Vol.971 (1), p.366-370
Main Author: TISCHLER, ARTHUR S.
Format: Article
Language:English
Subjects:
Animals
APUD cell
APUD Cells
Cattle
chromaffin cell
Chromaffin Cells - cytology
Chromaffin Cells - metabolism
Chromogranins - metabolism
Ectoderm - cytology
Endocrine System - cytology
Humans
Membrane Glycoproteins - metabolism
Membrane Transport Proteins
Mice
Neurons - metabolism
Neurons - physiology
Neuropeptides
paraganglia
paraneuron
PC12 Cells
PC12 MPC
pheochromocytoma
Rats
Vesicular Biogenic Amine Transport Proteins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: Chromaffin cells have many functional similarities to amine‐ and peptide‐producing endocrine cells throughout the body and to both peripheral and central neurons. The hypothesis of a shared, neural origin for chromaffin cells and most other endocrine cells is not tenable. However, chromaffin cells and their neoplastic counterparts, known as pheochromocytomas, are valuable models for studies of endocrine and neural properties. In this session, PC12 rat pheochromocytoma cells are used in two novel applications: to identify profiles of gene expression that may mediate cell death in neurodegenerative disorders and to study mechanisms for transduction of hypoxic signals. Recently described pheochromocytoma cell lines from neurofibromatosis knockout mice are shown to be novel models for signaling by the receptor tyrosine kinase ret, and purified enterochromaffin‐like (ECL) cells are shown to offer new opportunities to study the shared and distinctive aspects of neuroendocrine function using a normal cell type.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2002.tb04498.x