Expression of CD64 as a potential marker of neonatal sepsis

• Published in: Pediatric allergy and immunology 2002-10, Vol.13 (5), p.319-327
• Main Authors: Layseca-Espinosa, Esther, Pérez-González, Luis F., Torres-Montes, Abraham, Baranda, Lourdes, De La Fuente, Hortensia, Rosenstein, Yvonne, González-Amaro, Roberto
• Format: Article
• Language: English
• Subjects: adhesion molecules; Antigens, CD - biosynthesis; Antigens, CD - blood; Biomarkers - blood; cytokines; Cytokines - biosynthesis; Cytokines - blood; FcgRI; Humans; Infant Welfare; Infant, Newborn; Infant, Newborn, Diseases - diagnosis; Infant, Newborn, Diseases - metabolism; interleukin-1; Klebsiella Infections - diagnosis; Klebsiella Infections - metabolism; Klebsiella pneumoniae; Membrane Glycoproteins; Membrane Proteins - biosynthesis; Mexico; Neutrophils - metabolism; newborn; Platelet Glycoprotein GPIb-IX Complex; Predictive Value of Tests; Receptors, IgG - biosynthesis; Receptors, IgG - blood; Sensitivity and Specificity; Sepsis - diagnosis; Sepsis - metabolism
• ISSN: 0905-6157; 1399-3038
• DOI: 10.1034/j.1399-3038.2002.01064.x

The aim of this study was to identify a novel immunological indicator useful for the early diagnosis (through a rapid and single determination) of neonatal sepsis (NS). Peripheral blood samples were taken from 63 neonates, who were classified into four groups: proven NS (n = 17); clinical NS (n = 14); disease without infection (n = 17); and healthy newborns (n = 15). Neutrophil expression of CD64, CD43, CD44, CD50, CD62L and Mac‐1, and plasma levels of interleukin (IL)‐1β, IL‐6, tumor necrosis factor‐α (TNF‐α) and soluble L‐selectin (sCD62L), were determined. Expression of CD64 was significantly enhanced in the group with proven sepsis and clinical NS compared to newborns without infection (p