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Low-Grade Tubular-Mucinous Renal Neoplasms: Morphologic, Immunohistochemical, and Genetic Features

The current classification system of renal tumors is based on morphologic criteria, as supported by genetic findings. We present a group of previously unclassified tumors with similar morphologic and genetic features, suggesting a new entity within renal neoplasms. Seven renal tumors from five patie...

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Bibliographic Details
Published in:Modern pathology 2002-11, Vol.15 (11), p.1162-1171
Main Authors: Rakozy, C, Schmahl, G. E, Bogner, S, Störkel, S
Format: Article
Language:English
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Summary:The current classification system of renal tumors is based on morphologic criteria, as supported by genetic findings. We present a group of previously unclassified tumors with similar morphologic and genetic features, suggesting a new entity within renal neoplasms. Seven renal tumors from five patients (ages 31–67 years) were analyzed. All cases were stained with periodic acid–Schiff, Hale's colloidal iron (HCI), and Alcian blue (AB) at pH 2.5/1.0 with and without hyaluronidase (HA) digestion. Immunohistochemical (IHC) stains were performed for CK8, CK18, CK19, vimentin, villin, Tamm-Horsfall protein (THP), renal cell carcinoma marker (RCC), epithelial membrane antigen (EMA), ulex europaeus agglutinin (UEA-1), soy bean agglutinin (SBA), peanut agglutinin (PNA), and MIB-1. Comparative genomic hybridization (CGH) and loss of heterozygosity (LOH) studies were performed on all cases. All tumors showed circumscribed growth, a tubular growth pattern with focal solid areas, no significant nuclear atypia and absence of necrosis, desmoplasia, or inflammation. Abundant extracellular mucin was present. Immunohistochemistry stains support collecting duct origin (EMA+, PNA+, SBA±, CK 8/18/19+, vimentin±, UEA-1−, RCC−, villin−, THP−). The proliferative rate was low (
ISSN:0893-3952
1530-0285
DOI:10.1097/01.MP.0000031709.40712.46