A kinetic study of the chemical stability of the antimetastatic ruthenium complex NAMI-A

NAMI-A is a novel ruthenium complex with selective activity against cancer metastases currently in Phase I clinical trials in The Netherlands. The chemical stability of this new agent was investigated utilizing a stability-indicating reversed-phase high performance liquid chromatographic assay with...

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Bibliographic Details
Published in:International journal of pharmaceutics 2002-11, Vol.248 (1), p.239-246
Main Authors: Bouma, Marjan, Nuijen, Bastiaan, Jansen, Martine T, Sava, Gianni, Flaibani, Antonella, Bult, Auke, Beijnen, Jos H
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacokinetics
Biological and medical sciences
Chemical stability
Chemotherapy
Dimethyl Sulfoxide - analogs & derivatives
Dimethyl Sulfoxide - chemistry
Dimethyl Sulfoxide - pharmacokinetics
Drug Stability
General pharmacology
High performance liquid chromatography (HPLC)
Medical sciences
NAMI-A
Neoplasm Metastasis - prevention & control
Organometallic Compounds - chemistry
Organometallic Compounds - pharmacokinetics
Pharmacokinetics
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Ruthenium - chemistry
Ruthenium - pharmacokinetics
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Summary:NAMI-A is a novel ruthenium complex with selective activity against cancer metastases currently in Phase I clinical trials in The Netherlands. The chemical stability of this new agent was investigated utilizing a stability-indicating reversed-phase high performance liquid chromatographic assay with ultraviolet detection and ultraviolet/visible light spectrophotometry. The degradation kinetics of NAMI-A were studied as a function of pH, buffer composition, and temperature. Degradation of NAMI-A follows first-order kinetics at pH
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(02)00460-X