Evaluation of percutaneous absorption of 4-nerolidylcathecol from four topical formulations

Antioxidants such as vitamins E and C are known to play a significant role in ameliorating or preventing oxidative damage to the skin. However, to provide a satisfactory protection they must first permeate the skin, which serves as a permeation barrier. In this study we evaluated the influence of th...

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Bibliographic Details
Published in:International journal of pharmaceutics 2002-12, Vol.249 (1), p.109-116
Main Authors: Röpke, Cristina D, Kaneko, Telma M, Rodrigues, Renata M, da Silva, Vanessa V, Barros, Sonia, Sawada, Tânia C.H, Kato, Massuo J, Barros, Silvia B.M
Format: Article
Language:English
Subjects:
4-Nerolidylcathecol
Administration, Cutaneous
Administration, Topical
Animals
Antioxidant
Biological and medical sciences
Biomechanics. Biorheology
Catechols - administration & dosage
Catechols - pharmacokinetics
Chemistry, Pharmaceutical
Drug Evaluation, Preclinical - methods
Fundamental and applied biological sciences. Psychology
General pharmacology
Male
Medical sciences
Mice
Mice, Hairless
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Piperaceae
Plant Extracts - administration & dosage
Plant Extracts - pharmacokinetics
Plant Roots
Skin Absorption - drug effects
Skin Absorption - physiology
Skin permeation
Tissues, organs and organisms biophysics
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Summary:Antioxidants such as vitamins E and C are known to play a significant role in ameliorating or preventing oxidative damage to the skin. However, to provide a satisfactory protection they must first permeate the skin, which serves as a permeation barrier. In this study we evaluated the influence of three different formulations (gel, gel–emulsion and emulsion) on the percutaneous absorption of 4-nerolidylcathecol, an antioxidant compound isolated from Pothomorphe umbellata root extracts. Also, the absorption of the isolated 4-nerolidylcathecol was compared with its absorption when dried P. umbellata root ethanolic extract was incorporated into a gel formulation. The ‘lag time method’ was employed for the analysis of the in vitro permeation data. All formulations showed satisfactory percutaneous penetration with the 4-nerolidylcathecol–gel presenting a higher rate of penetration leading to higher dry drug levels in the tissue.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(02)00477-5