Morphologic Subtyping of Papillary Renal Cell Carcinoma: Correlation with Prognosis and Differential Expression of MUC1 between the Two Subtypes

Papillary renal cell carcinoma is now a well-established entity with distinct histological and cytogenetic features. A subdivision has been proposed in correlation with prognosis. Type 1 is the most frequent subtype and appears to have a better prognosis than Type 2. The subdivision is based on micr...

Full description

Saved in:
Bibliographic Details
Published in:Modern pathology 2002-11, Vol.15 (11), p.1126-1130
Main Authors: Leroy, Xavier, Zini, Laurent, Leteurtre, Emmanuelle, Zerimech, Farid, Porchet, Nicole, Aubert, Jean-Pierre, Gosselin, Bernard, Copin, Marie-Christine
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibodies
Carcinoma, Papillary - classification
Carcinoma, Papillary - metabolism
Carcinoma, Papillary - pathology
Carcinoma, Renal Cell - classification
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - pathology
Diagnosis, Differential
Female
Humans
Immunohistochemistry
Kidney cancer
Kidney Neoplasms - classification
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Laboratory Medicine
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
Morphology
MUC1
Mucin-1 - biosynthesis
Nuclear grade
original-article
Papillary renal cell carcinoma
Pathology
Prognosis
Survival Analysis
Tumors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Papillary renal cell carcinoma is now a well-established entity with distinct histological and cytogenetic features. A subdivision has been proposed in correlation with prognosis. Type 1 is the most frequent subtype and appears to have a better prognosis than Type 2. The subdivision is based on microscopic criteria. To investigate these 2 types of papillary renal cell carcinoma, we have compared the clinical features, ancillary factors (TNM stage, Fuhrman grade), survival and MUC1 expression in 25 Type 1 and 12 Type 2 papillary renal cell carcinomas. Type 2 tumors were significantly associated with a higher Fuhrman grade (Grade III frequent; P < .001). Type 2 tumors were also associated with a poorer prognosis than Type 1 (P < .005). Fuhrman grade was significantly associated with prognosis (P < .005). The type and the prognosis were not correlated with the TNM stage. We have shown a differential expression of MUC1 between Type 1 and Type 2 with a polarized expression in Type 1 and a rare expression in Type 2. In conclusion we confirm that the morphologic sub-typing and Fuhrman grade are valuable factors of outcome of papillary renal cell carcinomas and that MUC1 immunostaining is useful in differentiating Type 1 and Type 2 tumors.
ISSN:0893-3952
1530-0285
DOI:10.1097/01.MP.0000036346.88874.25