Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins

The copines are a novel family of ubiquitous Ca(2+)-dependent, phospholipid-binding proteins. They contain two Ca(2+)- and phospholipid-binding domains known as 'C2 domains' present in proteins such as protein kinase C, phospholipase C and synaptotagmin. Copines are thought to be involved...

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Published in:Cellular and molecular life sciences : CMLS 2002-09, Vol.59 (9), p.1467
Main Authors: Tomsig, J L, Creutz, C E
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Arabidopsis Proteins - chemistry
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Calcium - metabolism
Carrier Proteins - chemistry
Carrier Proteins - classification
Carrier Proteins - genetics
Carrier Proteins - metabolism
Humans
Molecular Sequence Data
Phospholipids - metabolism
Phylogeny
Protein Binding
Sequence Alignment
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creator Tomsig, J L
Creutz, C E
description The copines are a novel family of ubiquitous Ca(2+)-dependent, phospholipid-binding proteins. They contain two Ca(2+)- and phospholipid-binding domains known as 'C2 domains' present in proteins such as protein kinase C, phospholipase C and synaptotagmin. Copines are thought to be involved in membrane-trafficking phenomena because of their phospholipid-binding properties. They may also be involved in protein-protein interactions since they contain a domain similar to the protein-binding 'A domain' of integrins. The biochemistry, gene structure, tissue distribution and possible biological roles of copines are discussed, including recent observations with Arabidopsis that indicate that copines may be involved in cell division and growth.
doi_str_mv 10.1007/s00018-002-8522-7
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subjects Amino Acid Sequence
Animals
Arabidopsis Proteins - chemistry
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Calcium - metabolism
Carrier Proteins - chemistry
Carrier Proteins - classification
Carrier Proteins - genetics
Carrier Proteins - metabolism
Humans
Molecular Sequence Data
Phospholipids - metabolism
Phylogeny
Protein Binding
Sequence Alignment
title Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins
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