Hereditary breast and ovarian cancer in Asia: genetic epidemiology of BRCA1 and BRCA2

Ethnic differences in cancer incidence and mortality result from differences in genetic and epidemiologic risk factors. Mutations in BRCA1 and BRCA2 account for a small proportion of all breast cancer cases, but for a much higher proportion of cases with a strong family history of breast or ovarian...

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Bibliographic Details
Published in:Human mutation 2002-12, Vol.20 (6), p.413-424
Main Authors: Liede, Alexander, Narod, Steven A.
Format: Article
Language:English
Subjects:
Asia
Asia - epidemiology
BRCA1
BRCA1 Protein - genetics
BRCA2
BRCA2 Protein - genetics
breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - genetics
China
Female
founder effect
founder mutations
Humans
India
Iran
Japan
Mutation
Ovarian cancer
Ovarian Neoplasms - epidemiology
Ovarian Neoplasms - genetics
Pakistan
Philippines
Singapore
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Summary:Ethnic differences in cancer incidence and mortality result from differences in genetic and epidemiologic risk factors. Mutations in BRCA1 and BRCA2 account for a small proportion of all breast cancer cases, but for a much higher proportion of cases with a strong family history of breast or ovarian cancer. Germline mutations in BRCA1 and BRCA2 have been identified in individuals of many races and ethnic groups and the frequency of mutations varies between these groups. Some of the differences in cancer risk between populations may be the result of founder mutations in these genes. The cost and time required for mutation analysis are reduced considerably when founder mutations are identified for a specific ethnic group. The BRCA2 999del5 mutation in Iceland and three BRCA mutations in Ashkenazi Jews are well characterized. However, considerably less is known about the contribution of mutations in the BRCA1 and BRCA2 genes outside of European groups. Studies conducted on the Asian populations described here have expanded our current knowledge of genetic susceptibility and its contribution to breast and ovarian cancer rates in Asian populations. Hum Mutat 20:413–424, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:1059-7794
1098-1004
DOI:10.1002/humu.10154