Pharmacokinetics of teicoplanin in hemodialysis patients

As only insufficient knowledge about the dosage of teicoplanin in hemodialysis patients exists, a clinical trial was performed on 26 patients. An initial dose of 800 mg teicoplanin, followed by doses of 400 mg on day 8 and day 15, was administered. In addition to the common clinical parameters (feve...

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Bibliographic Details
Published in:Infection 1991-09, Vol.19 (5), p.324-327
Main Authors: HÖFFLER, D, KOEPPE, P, NAUMANN, E, LANG, E, SÖRGEL, F
Format: Article
Language:English
Subjects:
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Infections - drug therapy
Bacterial Infections - metabolism
Biological and medical sciences
Drug Administration Schedule
Female
Glycopeptides - administration & dosage
Glycopeptides - blood
Glycopeptides - pharmacokinetics
Glycopeptides - therapeutic use
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Renal Dialysis
Teicoplanin
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Summary:As only insufficient knowledge about the dosage of teicoplanin in hemodialysis patients exists, a clinical trial was performed on 26 patients. An initial dose of 800 mg teicoplanin, followed by doses of 400 mg on day 8 and day 15, was administered. In addition to the common clinical parameters (fever, white blood cell count, C-reactive protein), the plasma concentrations of this substance were determined. The HLTterm was 159 +/- 35 h, the Vss 104 +/- 25 1/100 kg and the CLtot 5.3 +/- 1.3 ml/min. It could be shown that the dosage regimen mentioned above produced long-lasting and highly effective levels, sufficiently surpassing the MICs of the expected bacteria (streptococci and staphylococci). The easily administered substance showed no adverse side effects, based on clinical criteria. The above-mentioned therapy nearly always resulted in success according to clinical criteria. Therefore, and due to its easy administration, it seems advantageous to start treatment with teicoplanin in hemodialysis patients obviously suffering from bacterial infections.
ISSN:0300-8126
1439-0973
DOI:10.1007/bf01645356