Influence of the inhibition of free-radical oxidation processes in early postnatal ontogenesis on learning in adult rats

The influence of the neonatal administration of the synthetic antioxidant mexidol on teaching rats an active avoidance conditioned reflex at the age of two months was studied. It was established that the inhibition of free-radical oxidation in the tissues of three to seven day old infant rats subseq...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 1991-11, Vol.21 (6), p.568-571
Main Authors: Vishnevskaya, G V, Gern, E I, Adzhimolaev, T A
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - physiology
Antioxidants - pharmacology
Avoidance Learning - drug effects
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Free Radicals
Learning - drug effects
Learning - physiology
Motor Activity - drug effects
Oxidation-Reduction
Picolines - pharmacology
Rats
Rats, Inbred Strains
Synaptosomes - drug effects
Synaptosomes - metabolism
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Summary:The influence of the neonatal administration of the synthetic antioxidant mexidol on teaching rats an active avoidance conditioned reflex at the age of two months was studied. It was established that the inhibition of free-radical oxidation in the tissues of three to seven day old infant rats subsequently leads to facilitation of the learning process: to a decrease in the latent period of the avoidance reaction by a factor of 4-6, a two-fold increase in the conditioned reflex response, and a decrease in total motoric activity at the stage of the stably developed reaction.
ISSN:0097-0549
1573-899X
DOI:10.1007/BF01185951