The nuclear pore complex and chromatin boundaries

The organization of the chromatin fiber within specific nuclear compartments and its arrangement into domains of higher-order structure are aspects of the regulation of gene expression that remain largely undefined. Boundary and insulator elements are likely to play important roles in establishing a...

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Bibliographic Details
Published in:Trends in cell biology 2002-10, Vol.12 (10), p.452-455
Main Authors: Pai, Chi-Yun, Corces, Victor G
Format: Article
Language:English
Subjects:
boundary element
Chromatin - physiology
fusion protein
gene expression
gene regulation silencing
nuclear lamina
Nuclear Pore - physiology
nuclear pore comple (NPC)
nuclear transport
Sir protein
telomere
yeast
Yeasts - physiology
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Summary:The organization of the chromatin fiber within specific nuclear compartments and its arrangement into domains of higher-order structure are aspects of the regulation of gene expression that remain largely undefined. Boundary and insulator elements are likely to play important roles in establishing and maintaining the nuclear architecture required by eukaryotic cells to orchestrate the intricate array of events such as DNA replication, transcription and RNA processing. Recent results suggest a link between chromatin organization and nuclear transport and offer a glimpse of how nuclear organization might facilitate the integration of complex nuclear processes. Recent results suggest a link between chromatin organization and nuclear transport and offer a glimpse of how nuclear organization, especially pore components, might facilitate the integration of complex nuclear processes.
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(02)02367-X