Spontaneous Basaloid Adenomas of the Mammary Gland in Four Dogs: Clinicopathologic and Immunohistochemical Features

Spontaneous basaloid adenomas occurred in four out of 354 dogs with mammary tumors. Affected dogs were pure-bred, intact females between 6 and 8 years of age. Three dogs were nuliparous, two had pseudopregnancies, and none had received contraceptive steroids. The tumors were multiple (three cases) o...

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Bibliographic Details
Published in:Veterinary pathology 2002-11, Vol.39 (6), p.739-743
Main Authors: de las Mulas, J. Martín, Ordás, J., Millán, M. Y., de los Monteros, A. Espinosa, Reymundo, C.
Format: Article
Language:English
Subjects:
Adenoma - metabolism
Adenoma - pathology
Adenoma - veterinary
Animals
Calcium-Binding Proteins - metabolism
Calponins
Dog Diseases - metabolism
Dog Diseases - pathology
Dogs
Female
Immunohistochemistry - veterinary
Keratins - metabolism
Mammary Neoplasms, Animal - metabolism
Mammary Neoplasms, Animal - pathology
Microfilament Proteins
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Summary:Spontaneous basaloid adenomas occurred in four out of 354 dogs with mammary tumors. Affected dogs were pure-bred, intact females between 6 and 8 years of age. Three dogs were nuliparous, two had pseudopregnancies, and none had received contraceptive steroids. The tumors were multiple (three cases) or unique, less than 1 cm in diameter, well delineated, and composed of uniform cords and clusters of monomorphic epithelial cells with focal signs of squamous or glandular differentiation. A basal cell immunophenotype (cytokeratins 5 and 14 positive) without either glandular epithelial (cytokeratins 8, 18, and 19 negative) or myoepithelial (calponin negative) differentiation was observed in the majority of tumor cells. No recurrence or metastasis was recorded after follow-up periods between 3 and 24 months. In spite of the hormone-dependent nature of this tumor in female Beagles given experimental contraceptive steroids, spontaneous basaloid adenomas lacked estrogen receptor alpha and progesterone receptors.
ISSN:0300-9858
1544-2217
DOI:10.1354/vp.39-6-739