Effects of chronic acetyl-L-carnitine treatment on brain lipid hydroperoxide level and passive avoidance learning in senescence-accelerated mice

In the present study, we examined the effects of acetyl-L-carnitine (ALC) on the brain lipid hydroperoxide level and on passive avoidance performance in senescence-acceleration-prone 8 mice (SAMP8). Mice were treated intraperitoneally with either saline or ALC (100 or 400 mg/kg) three times a week u...

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Bibliographic Details
Published in:Neuroscience letters 2002-12, Vol.334 (3), p.177-180
Main Authors: YASUI, Fumihiko, MATSUGO, Seiichi, ISHIBASHI, Masaru, KAJITA, Takahiro, EZASHI, Yoshiharu, OOMURA, Yutaka, KOJO, Shosuke, SASAKI, Kazuo
Format: Article
Language:English
Subjects:
Acetylcarnitine - pharmacology
Aging - physiology
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Development. Senescence. Regeneration. Transplantation
Disease Models, Animal
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Lipid Peroxides - metabolism
Male
Mice
Mice, Inbred Strains
Nootropic Agents - pharmacology
Reaction Time - physiology
Statistics as Topic
Vertebrates: nervous system and sense organs
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Summary:In the present study, we examined the effects of acetyl-L-carnitine (ALC) on the brain lipid hydroperoxide level and on passive avoidance performance in senescence-acceleration-prone 8 mice (SAMP8). Mice were treated intraperitoneally with either saline or ALC (100 or 400 mg/kg) three times a week up to 4 months of age (starting at 3 weeks of age). In 4-month-old SAMP8, the deficit in learning and memory seen in saline-treated controls was significantly ameliorated in 400 mg/kg ALC-treated SAMP8, and the brain lipid hydroperoxide level was significantly lower in the 400 mg/kg ALC-treated group than in the saline-treated controls. Administration of 100 mg/kg ALC to SAMP8 did not have significant effect on learning and memory performance or on the brain lipid hydroperoxide level (by comparison with the saline-treated controls). These results suggest that ALC has antioxidant activity towards oxidative stress, and that the improvement in cognitive ability seen with ALC may occur through an amelioration of cellular dysfunction via an inhibition of the increase in lipid hydroperoxidation observed in the brain tissue of untreated SAMP8.
ISSN:0304-3940
1872-7972
DOI:10.1016/s0304-3940(02)01127-8