Effect of opiate receptor blockade on the insulin response to oral glucose load in polycystic ovarian disease

In order to test the hypothesis that endogenous opiates are at least partially responsible for hyperinsulinaemia in patients with polycystic ovarian disease (PCOD), the effect of naloxone (an opiate receptor blocker) on the insulin response to oral glucose load (OGTT) was studied in 20 women with PC...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1991-09, Vol.6 (8), p.1043-1049
Main Authors: Lanzone, A., Fulghesu, A.M., Fortini, A., Cutillo, G., Cucinelli, F., Simone, N.Di, Caruso, A., Mancuso, S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Blood Glucose - metabolism
Body Weight
Endorphins - physiology
Female
Female genital diseases
Glucose Tolerance Test
Gynecology. Andrology. Obstetrics
Humans
insulin
Insulin - blood
Medical sciences
Naloxone
Narcotic Antagonists
Non tumoral diseases
opioids
PCOD
Polycystic Ovary Syndrome - physiopathology
Space life sciences
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Summary:In order to test the hypothesis that endogenous opiates are at least partially responsible for hyperinsulinaemia in patients with polycystic ovarian disease (PCOD), the effect of naloxone (an opiate receptor blocker) on the insulin response to oral glucose load (OGTT) was studied in 20 women with PCOD and 17 control subjects at days 5–8 of their follicular phase. After fasting overnight for 10–12 h, each woman received an i.v. bolus injection (2 mg) of naloxone or an equal volume of saline infusion followed by a constant infusion of naloxone or saline solution at a rate of 8 ml/h (1 mg/h of naloxone) for 5 h. OGTT (75 g) was performed 1 h after the bolus Injection. The naloxone study was performed 48 h after the saline study. Naloxone did not modify the insulin response to OGTT in either group. When the data were related to the insulin response, in PCOD hyperinsulinaemic patients, naloxone significantly reduced (P
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a137482