Encoding-related brain activity during deep processing of verbal materials: a PET study

The recent advent of neuroimaging techniques provides an opportunity to examine brain regions related to a specific memory process such as episodic memory encoding. There is, however, a possibility that areas active during an assumed episodic memory encoding task, compared with a control task, invol...

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Bibliographic Details
Published in:Neuroscience research 2002-12, Vol.44 (4), p.429-438
Main Authors: Fujii, Toshikatsu, Okuda, Jiro, Tsukiura, Takashi, Ohtake, Hiroya, Suzuki, Maki, Kawashima, Ryuta, Itoh, Masatoshi, Fukuda, Hiroshi, Yamadori, Atsushi
Format: Article
Language:English
Subjects:
Adult
Brain Mapping
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - physiology
Encoding
Entorhinal cortex
Episodic memory
Functional Laterality - physiology
Humans
Language Tests
Levels of processing
Male
Medial temporal lobe
Memory
Memory - physiology
Nerve Net - anatomy & histology
Nerve Net - diagnostic imaging
Nerve Net - physiology
Neural Pathways - diagnostic imaging
Neural Pathways - physiology
Parahippocampal gyrus
Positron emission tomography
Psychomotor Performance - physiology
Speech Perception - physiology
Tomography, Emission-Computed
Verbal Behavior - physiology
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Summary:The recent advent of neuroimaging techniques provides an opportunity to examine brain regions related to a specific memory process such as episodic memory encoding. There is, however, a possibility that areas active during an assumed episodic memory encoding task, compared with a control task, involve not only areas directly relevant to episodic memory encoding processes but also areas associated with other cognitive processes for on-line information. We used positron emission tomography (PET) to differentiate these two kinds of regions. Normal volunteers were engaged in deep (semantic) or shallow (phonological) processing of new or repeated words during PET. Results showed that deep processing, compared with shallow processing, resulted in significantly better recognition performance and that this effect was associated with activation of various brain areas. Further analyses revealed that there were regions directly relevant to episodic memory encoding in the anterior part of the parahippocampal gyrus, inferior frontal gyrus, supramarginal gyrus, anterior cingulate gyrus, and medial frontal lobe in the left hemisphere. Our results demonstrated that several regions, including the medial temporal lobe, play a role in episodic memory encoding.
ISSN:0168-0102
1872-8111
DOI:10.1016/S0168-0102(02)00160-8