Effects of S 21403 on hormone secretion from isolated rat pancreas at different glucose concentrations

• Published in: European journal of pharmacology 2002-12, Vol.456 (1), p.141-147
• Main Authors: Gregorio, Franco, Ambrosi, Franca, Boemi, Massimo, Carle, Flavia, Filipponi, Paolo
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Carbamates - pharmacology; Dose-Response Relationship, Drug; General and cellular metabolism. Vitamins; Glibenclamide; Glucagon release; Glucose - pharmacology; Glyburide - pharmacology; Hypoglycemic Agents - pharmacology; In Vitro Techniques; Indoles - pharmacology; Insulin - metabolism; Insulin release; Insulin Secretion; Isoindoles; isolated, rat; Male; Medical sciences; Pancreas; Pancreas - drug effects; Pancreas - metabolism; Pharmacology. Drug treatments; Piperidines - pharmacology; Rats; Rats, Sprague-Dawley; Repaglinide; S 21403; Time Factors
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/S0014-2999(02)02620-1

We investigated the in vitro effects of therapeutical concentrations of S 21403 (a succinic acid derivative also known as KAD 1229 and mitiglinide) on insulin and glucagon secretion during a metabolic stimulus (glucose rising from 5 to 8.33 mM) or at a stable 2.22 mM glucose using the isolated perfused rat pancreas model, and we compared them with the patterns of repaglinide and glibenclamide. Control perfusions were also performed. During 8.33 mM glucose, insulin release peaked to 339.12±22.87 μU/ml in controls. S 21403 enhanced insulin release (first peak 413.02±14.90 μU/ml; P