Correlation between Variation of the 3′ Region of the cagA Gene in Helicobacter pylori and Disease Outcome in Japan

Genetic diversity within the cag pathogenicity island (PAI) of Helicobacter pylori may have a modifying effect on the pathogenic potential of the infecting strain. The genetic structure of the cag PAI was examined in Japanese isolates. The composition and nucleotide sequences of the cag PAI were qui...

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Bibliographic Details
Published in:The Journal of infectious diseases 2002-12, Vol.186 (11), p.1621-1630
Main Authors: Azuma, Takeshi, Yamakawa, Akiyo, Yamazaki, Shiho, Fukuta, Kanako, Ohtani, Masahiro, Ito, Yoshiyuki, Dojo, Manabu, Yamazaki, Yukinao, Kuriyama, Masaru
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigens, Bacterial
Atrophic gastritis
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological and medical sciences
Disease Progression
Epithelial cells
Female
Gastritis
Gastritis, Atrophic - microbiology
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Diseases - microbiology
Genetic diversity
Genetic Variation
Genotypes
Geographic regions
Health outcomes
Helicobacter Infections - complications
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori - pathogenicity
Human bacterial diseases
Humans
Infectious diseases
Japan
Male
Medical sciences
Middle Aged
Molecular Sequence Data
Nucleotide sequences
Other diseases. Semiology
Polymerase chain reaction
Sequence Alignment
Sequence Analysis, DNA
Stomach Neoplasms - microbiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Virulence
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Summary:Genetic diversity within the cag pathogenicity island (PAI) of Helicobacter pylori may have a modifying effect on the pathogenic potential of the infecting strain. The genetic structure of the cag PAI was examined in Japanese isolates. The composition and nucleotide sequences of the cag PAI were quite similar among strains; however, diversity between 2 cag genes (virB10 and cagA) was observed. The variety in the number of repetition of the 5–amino acid sequence R1 (EPIYA) in the 3′ region of the cagA gene was identified. The frequencies of the genotypes that contained >4 R1 sequences were significantly higher in atrophic gastritis–causing strains than in duodenal ulcer–causing strains. One-third of strains with >4 R1 sequences were gastric cancer–causing strains. Although the cag PAI is conserved in H. pylori isolates in Japan, H. pylori infection with the cagA genotype with >4 R1 sequences may correlate with the pathogenesis of atrophic gastritis and gastric cancer
ISSN:0022-1899
1537-6613
DOI:10.1086/345374