Breast carcinoma: a report on the potential usage of the CC chemokine RANTES as a marker for a progressive disease

High incidence and intensity of RANTES (CC chemokine) expression were noted in advanced breast carcinoma. To present two cases of breast carcinoma patients in whom RANTES expression was analyzed in parallel to disease progression. Although no evidence of malignancy was detected in the axillary lymph...

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Bibliographic Details
Published in:The Israel Medical Association journal 2002-11, Vol.4 (11 Suppl), p.940-943
Main Authors: Wigler, Nely, Shina, Sima, Kaplan, Ofer, Luboshits, Galia, Chaitchik, Samario, Keydar, Iafa, Ben-Baruch, Adit
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - analysis
Biomarkers, Tumor - genetics
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - pathology
Case-Control Studies
Chemokine CCL5 - analysis
Chemokine CCL5 - genetics
Chemokines, CC - analysis
Chemokines, CC - genetics
Disease Progression
Female
Gene Expression Regulation, Neoplastic - genetics
Humans
Immunohistochemistry - methods
Immunohistochemistry - standards
Middle Aged
Predictive Value of Tests
Pregnancy
Pregnancy Complications, Neoplastic - pathology
Prognosis
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Summary:High incidence and intensity of RANTES (CC chemokine) expression were noted in advanced breast carcinoma. To present two cases of breast carcinoma patients in whom RANTES expression was analyzed in parallel to disease progression. Although no evidence of malignancy was detected in the axillary lymph nodes of the two patients, their disease progressed. The expression of RANTES in both patients was positive at diagnosis and predicted the clinical course. These results, combined with our previous findings on the correlation between RANTES expression and advanced breast carcinoma, suggest that the assessment of RANTES expression may be useful for the identification of patients with apparently poor prognosis who may benefit from aggressive treatment. The above results call for large-scale studies by numerous research groups to determine the prognostic value of RANTES expression.
ISSN:1565-1088