Dolichol levels in younger and older rat hearts heterotopically transplanted in younger recipients

Dolichol (D) levels increase dramatically in older tissue. An understanding of the exchangeability of D between tissues may be essential in order to understand the mechanism of the abnormal accumulation associated with aging. The question was investigated by the use of organ transplantation. D‐poor...

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Bibliographic Details
Published in:Lipids 2002-09, Vol.37 (9), p.913-916
Main Authors: Cavallini, Gabriella, Parentini, Ilaria, Di Stefano, Rossella, Maccheroni, Marco, Masini, Matilde, Pollera, Maria, Gori, Zina, Masca, Franco, Bergamini, Ettore
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Chromatography, High Pressure Liquid
Dolichol - analysis
Heart Transplantation
Male
Myocardium - chemistry
Myocardium - cytology
Nutrition
Organ Size
Rats
Rats, Inbred Strains
Rats, Sprague-Dawley
Tissue Donors
Tissues
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Summary:Dolichol (D) levels increase dramatically in older tissue. An understanding of the exchangeability of D between tissues may be essential in order to understand the mechanism of the abnormal accumulation associated with aging. The question was investigated by the use of organ transplantation. D‐poor hearts donated by 3‐mon‐old and D‐rich by 22‐mon‐old male Lewis rats were transplanted heterotopically in 3‐mon‐old syngenic recipients, whose peripheral tissues and liver were poor in D. Native and transplanted hearts were taken 7 and 21 d after surgery. Native hearts of 3‐mon‐ and 22‐mon‐old male Lewis rats served as control. D concentration and quantity were higher in older than in younger native hearts as expected. In the transplanted hearts, the quantity of D was unchanged, irrespective of the age of the donor and of the time of transplantation, whereas D concentration increased because of the remarkable disuse atrophy. No changes in D were observed in recipients’ tissues. It is concluded that dolichol is not redistributed via circulation from the transplanted heart to the tissues and liver of the younger recipient.
ISSN:0024-4201
1558-9307
DOI:10.1007/s11745-002-0979-y