Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease : results of a double-blind placebo-controlled study

The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxyge...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1991-01, Vol.41 (6), p.511-515
Main Authors: CIUFFETTI, G, MERCURI, M, OTT, C, LOMBARDINI, R, PALTRICCIA, R, LUPATTELLI, G, SANTAMBROGIO, L, MANNARINO, E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular system
Cross-Sectional Studies
Double-Blind Method
Female
Free Radicals - antagonists & inhibitors
Free Radicals - metabolism
Humans
Leukocytes - metabolism
Longitudinal Studies
Male
Medical sciences
Middle Aged
Oxygen - metabolism
Pentoxifylline - administration & dosage
Pentoxifylline - metabolism
Pentoxifylline - pharmacology
Peripheral Vascular Diseases - metabolism
Pharmacology. Drug treatments
Risk Factors
Superoxides - metabolism
Time Factors
Vasodilator agents. Cerebral vasodilators
Walking
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Summary:The effects of an infusion of pentoxifylline 1 g as an inhibitor of free radical generation have been determined in a double-blind placebo-controlled study. Leucocyte-derived free radical generation (by the superoxide dismutase-inhibitable reduction of ferricytochrome), the release of reactive oxygen metabolites (as plasma oxidant activity), unfractionated leucocyte and erythrocyte filterability rates (using a constant-flow positive-pressure system), plasma viscosity, and plasma fibrinogen concentration have been measured in two matched groups of 10 patients with Stage II peripheral vascular disease, before and after treatment. Transcutaneous oxygen pressure (PtcO2) during treadmill exercise to stress leg circulation was also measured. Leucocyte-derived free radicals were generated during peripheral ischaemia. Pentoxifylline inhibited their generation, blocked the release of reactive oxygen metabolites, and reduced impairment of the filterability rate of unfractionated leucocytes. The improvements were accompanied by significant shortening of the half-time of recovery of transcutaneous oxygen pressure, indicating that ischaemic damage had been contained.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00314976