In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes

Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concen...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-06, Vol.133 (6), p.614-616
Main Authors: Kazakova, T B, Barabanova, S V, Khavinson, V Kh, Glushikhina, M S, Parkhomenko, E P, Malinin, V V, Korneva, E A
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Dipeptides - pharmacology
Dose-Response Relationship, Drug
Gene Expression - drug effects
Interleukin-2 - genetics
Mice
Mice, Inbred CBA
Oligopeptides - pharmacology
Peptides - chemistry
Peptides - pharmacology
Spleen - cytology
Spleen - drug effects
Time Factors
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Summary:Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors. The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1020210615148