Cellular immunodeficiency in Paget's disease of bone : changes induced by treatment with elcatonin

We have found a cellular immune defect (low CD4 T lymphocyte count, high CD8 T lymphocyte count and a low CD4/CD8 ratio) in 39 PDB patients. This finding is not correlated with the bone metabolic activity of the disease. There was an improvement in the cellular immune defect in fifteen patients afte...

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Bibliographic Details
Published in:Calcified tissue international 1991-12, Vol.49 (6), p.436-437
Main Authors: RAPADO, A, YAGUE, M, DIAZ CURIEL, M, ORTIZ, F, PALOMINO, P, DE LA PIEDRA, C, TORRES, R, PERAMO, B, LOPEZ GAVILANES, E
Format: Article
Language:English
Subjects:
Aged
AIDS/HIV
Biological and medical sciences
Calcitonin - analogs & derivatives
Calcitonin - therapeutic use
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes - immunology
Diseases of the osteoarticular system
Female
Humans
Leukocyte Count
Male
Medical sciences
Middle Aged
Osteitis Deformans - drug therapy
Osteitis Deformans - immunology
Osteoporosis. Osteomalacia. Paget disease
T-Lymphocytes - immunology
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Summary:We have found a cellular immune defect (low CD4 T lymphocyte count, high CD8 T lymphocyte count and a low CD4/CD8 ratio) in 39 PDB patients. This finding is not correlated with the bone metabolic activity of the disease. There was an improvement in the cellular immune defect in fifteen patients after treatment with elcatonin. These changes could be related to the improvement in the metabolic derangement or else could be the consequence of an effect on altered immunity.
ISSN:0171-967X
1432-0827
DOI:10.1007/bf02555857