A model of myocarditis

Myocarditis was induced by synergic interactions of serotonin- and cholinergic nerve fibers during potentiation of vagal inhibition of cardiac activity by stimulation of the stellate ganglion. Thus modeled myocarditis was associated with increased content of serotonin and decreased concentrations of...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2002-07, Vol.134 (1), p.98-99
Main Author: Lychkova, A E
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
Animals
Disease Models, Animal
Myocardial Contraction - drug effects
Myocarditis - pathology
Myocarditis - physiopathology
Norepinephrine - metabolism
Rabbits
Receptors, Serotonin - metabolism
Serotonin - metabolism
Serotonin Antagonists - pharmacology
Stellate Ganglion - pathology
Vagus Nerve - pathology
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Summary:Myocarditis was induced by synergic interactions of serotonin- and cholinergic nerve fibers during potentiation of vagal inhibition of cardiac activity by stimulation of the stellate ganglion. Thus modeled myocarditis was associated with increased content of serotonin and decreased concentrations of acetylcholine and catecholamines in the myocardial tissue. Blockade of 5HT3(S3) receptors in autonomic ganglia and 5HT1,2(S1,2) receptors in the myocardium improved myocardial contractility and reduced the severity of myocarditis.
ISSN:0007-4888
1573-8221
DOI:10.1023/A:1020637528411