Erythrocyte choline uptake after renal transplantation

Erythrocyte membrane choline transport is abnormally high in chronic renal failure. The aim of this study was to find out whether, and how quickly, this abnormality is reversed by renal transplantation. Ten adults with chronic renal failure were studied before and for up to 6 months after renal tran...

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Bibliographic Details
Published in:The Lancet (British edition) 1992-01, Vol.339 (8786), p.146-148
Main Authors: Poli de Figueiredo, C.E., Ellory, J.C., Hendry, B.M.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cell Membrane Permeability - physiology
Choline - metabolism
Creatinine - blood
Erythrocyte Membrane - metabolism
Erythrocytes
Female
Follow-Up Studies
Humans
Kidney Failure, Chronic - metabolism
Kidney Transplantation
Kidneys
Male
Medical disorders
Medical research
Medical sciences
Middle Aged
Renal function
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Time Factors
Transplantation
Transplants & implants
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Summary:Erythrocyte membrane choline transport is abnormally high in chronic renal failure. The aim of this study was to find out whether, and how quickly, this abnormality is reversed by renal transplantation. Ten adults with chronic renal failure were studied before and for up to 6 months after renal transplantation. Plasma creatinine concentration and erythrocyte uptake of radiolabelled choline were measured periodically for up to 6 months. The maximum rate of choline transport (V max) was abnormally high before transplantation and fell to normal values during the first week after transplantation. This fall matched that in plasma creatinine. A temporary rise in plasma creatinine in one patient, reversed by methylprednisolone treatment, was accompanied by a rise in choline flux, and graft failure in another patient was accompanied by a return to pretransplant rates of choline transport. Thus, the high rates of choline uptake in uraemia are rapidly reduced on recovery of renal function. The speed of the changes suggests the involvement of a plasma factor.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(92)90211-K