High frequency stimulation-induced dendritic calcium waves in rat hippocampal neurons

An activity-dependent intracellular Ca 2+ increase represents a key signal for the activation of mechanisms involved in synaptic long-term plasticity. Here we present data from confocal microscopic imaging in conjunction with electrophysiological studies, that local 100 Hz stimulations of the hippoc...

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Bibliographic Details
Published in:Neuroscience letters 2002-12, Vol.335 (2), p.103-106
Main Authors: Jäger, Tino, Behnisch, Thomas, Reymann, Klaus G
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - pharmacology
Anesthetics, Local - pharmacology
Animals
Benzoates - pharmacology
Biological and medical sciences
Calcium
Calcium - metabolism
Calcium Signaling
Central nervous system
Dendrites - drug effects
Dendrites - metabolism
Electric Stimulation
Electrophysiology
Excitatory Amino Acid Agonists - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Fluorescent Dyes
Fundamental and applied biological sciences. Psychology
Glycine - analogs & derivatives
Glycine - pharmacology
Hippocampus
Hippocampus - cytology
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - physiology
Imaging
In Vitro Techniques
Lidocaine - analogs & derivatives
Lidocaine - pharmacology
Long-term potentiation
Male
Metabotropic glutamate receptors
Microscopy, Confocal
N-Methylaspartate - pharmacology
Neurons - drug effects
Neurons - metabolism
Neurons - physiology
Organic Chemicals
Rats
Rats, Wistar
Synaptic plasticity
Vertebrates: nervous system and sense organs
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Summary:An activity-dependent intracellular Ca 2+ increase represents a key signal for the activation of mechanisms involved in synaptic long-term plasticity. Here we present data from confocal microscopic imaging in conjunction with electrophysiological studies, that local 100 Hz stimulations of the hippocampal Schaffer collateral fibers, usually used for the induction of synaptic long-term potentiation (LTP), elicits an intradendritic Ca 2+ rise, that propagates as a short-distance wave within dendrites of CA1-neurons, which could be involved in triggering the dendritic (local signal cascade) machinery of LTP generation. Pharmacological investigations elucidated the coincidental involvement of N-methyl- d-aspartate- and of group I metabotropic glutamate receptors in the generation of the Ca 2+ wave.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(02)01165-5