Bradykinin sensitivity in primary open-angle glaucoma and normal-tension glaucoma patients

• Published in: American journal of ophthalmology 2002-12, Vol.134 (6), p.922-924
• Main Authors: Hirooka, Kazuyuki, Shiraga, Fumio, Hasegawa, Eiichi
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Bradykinin - pharmacology; Dermatitis, Allergic Contact - etiology; Dermatitis, Allergic Contact - metabolism; Female; Glaucoma and intraocular pressure; Glaucoma, Open-Angle - complications; Glaucoma, Open-Angle - metabolism; Humans; Injections; Intraocular Pressure; Kallikrein-Kinin System - physiology; Male; Medical sciences; Middle Aged; Ophthalmology; Prospective Studies; Retinopathies; Skin - drug effects; Skin Tests
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/S0002-9394(02)01703-8

To report the reaction after intradermal injection of bradykinin in nonglaucoma, primary open-angle glaucoma, and normal-tension glaucoma subjects. Prospective comparative study. The study participants were 14 healthy control subjects, 16 patients with primary open-angle glaucoma, and 15 patients with normal-tension glaucoma. In each participant, the wheal response to intradermal injection of 10 μg bradykinin in the volar forearm was measured by a masked observer. There was no significant difference in the wheal response to bradykinin between control subjects and primary open-angle glaucoma patients ( P = .73) and between primary open-angle glaucoma patients and normal-tension glaucoma patients ( P = .09). However, there was a significant difference in the wheal response to bradykinin between control subjects and normal-tension glaucoma patients ( P = .04). These in vivo structure-activity studies may suggest abnormalities of the tissue kallikrein-kinin system in normal-tension glaucoma.