Pharmacokinetic profiles of prazepam and 14C-prazepam in rat

Pharmacokinetics of Prazepam and 14C-Prazepam were studied in rat. Prazepam was measured in blood and plasma by a gas-liquid chromatography assay with an electron capture detector. Its major metabolite, Desmethyldiazepam, was also determined in blood in the same way. Total radioactivity was measured...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 1991, Vol.Spec No 3, p.3-8
Main Authors: Dios-Vieitez, M C, Renedo, M J, Fos, D
Format: Article
Language:English
Subjects:
Animals
Chromatography, Gas
Half-Life
Injections, Intravenous
Male
Nordazepam - blood
Prazepam - blood
Prazepam - pharmacokinetics
Rats
Rats, Inbred Strains
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Summary:Pharmacokinetics of Prazepam and 14C-Prazepam were studied in rat. Prazepam was measured in blood and plasma by a gas-liquid chromatography assay with an electron capture detector. Its major metabolite, Desmethyldiazepam, was also determined in blood in the same way. Total radioactivity was measured in plasma by scintillation spectrometry. Pharmacokinetic analysis were carried out by two ways; according to compartmental pharmacokinetic models and by statistic moments.
ISSN:0378-7966