Oxidative stress, vitamin A and vitamin E behaviour in patients submitted to conservative surgery for complicated Crohn's disease

Aims. To assess whether plasma peroxidation and plasma levels of antioxidant compounds are correlated with clinical and biochemical activity in complicated Crohn's disease patients, and to evaluate whether the relief of obstructive complication by conservative surgery has any effect on the oxid...

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Published in:Digestive and liver disease 2002-10, Vol.34 (10), p.696-701
Main Authors: Sampietro, G.M., Cristaldi, M., Cervato, G., Maconi, G., Danelli, P., Cervellione, R., Rovati, M., Bianchi Porro, G., Cestaro, B., Taschieri, A.M.
Format: Article
Language:English
Subjects:
Adult
Antioxidants - metabolism
Case-Control Studies
Crohn Disease - metabolism
Crohn Disease - surgery
Crohn's disease
Female
Humans
Lipid Peroxidation
Male
Oxidative Stress
strictureplasty
Thiobarbituric Acid Reactive Substances - metabolism
Time Factors
Vitamin A
Vitamin A - metabolism
Vitamin E
Vitamin E - metabolism
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Summary:Aims. To assess whether plasma peroxidation and plasma levels of antioxidant compounds are correlated with clinical and biochemical activity in complicated Crohn's disease patients, and to evaluate whether the relief of obstructive complication by conservative surgery has any effect on the oxidative stress. Patients and Methods. From May 1998 to May 2000, 20 Crohn's disease patients were studied. Basal peroxidative state (basal thiobarbituric acid reactive substances), peroxidative state after stimulation with copper sulfate (stimulated thiobarbituric acid reactive substances), lag time of plasma peroxidation susceptibility, plasma levels of vitamin E and A, C reactive protein, erythrocyte sedimentation rate and Crohn's disease activity index, were determined, before surgery, then 2 months and 1 year after surgery. A group of 134 healthy volunteers were used as controls. All patients were treated by conservative surgical procedures (i.e., strictureplasty and/or minimal resections). Student t test for paired and unpaired data and Spearman R correlation coefficient were calculated. Result. Peroxidative plasma levels, as well as inflammatory indices, are significantly reduced 2 months and 1 year after surgery (p
ISSN:1590-8658
1878-3562
DOI:10.1016/S1590-8658(02)80020-2