Loading…

Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome

A prospective randomized trial with a crossover design was conducted to compare the efficacy and safety of two distinct strategies of high-frequency oscillatory ventilation (HFOV) to conventional intermittent mandatory ventilation (CV) in the management of respiratory distress syndrome. Only prematu...

Full description

Saved in:
Bibliographic Details
Published in:Pediatrics (Evanston) 1992, Vol.89 (1), p.5-12
Main Authors: CLARK, R. H, GERSTMANN, D. R, NULL, D. M, DELEMOS, R. A
Format: Article
Language:English
Subjects:
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c350t-eab895886c9192a3d8be18063fadf231b5c342b6a0f8881cd8f31a34f6e559523
cites
container_end_page 12
container_issue 1
container_start_page 5
container_title Pediatrics (Evanston)
container_volume 89
creator CLARK, R. H
GERSTMANN, D. R
NULL, D. M
DELEMOS, R. A
description A prospective randomized trial with a crossover design was conducted to compare the efficacy and safety of two distinct strategies of high-frequency oscillatory ventilation (HFOV) to conventional intermittent mandatory ventilation (CV) in the management of respiratory distress syndrome. Only premature neonates with a birth weight less than 1.751 kg were eligible for enrollment into the study. Of 83 patients studied, 26 patients were assigned to CV-only, 27 to HFOV for 72 hours followed by CV (HFOV/CV), and 30 to HFOV-only until extubation. There was no difference among the three groups with respect to the incidence of pulmonary airleak, intraventricular hemorrhage, or death. The highest incidence of chronic lung disease was in the CV-only group. Although both HFOV groups had a lower incidence of chronic lung disease assessed at 30 days and 36 weeks postconception age, the difference was statistically significant only between the CV-only and HFOV-only groups (65% vs 30% at 30 days; P = .008; 38% vs 10% at 36 weeks postconception age, P = .013). These results suggest that use of HFOV as the predominant mode of ventilation in the management of respiratory distress syndrome is as safe as CV and can contribute to a decreased incidence of chronic lung disease. Furthermore, a short (72-hour) period of HFOV support does not provide the same advantage as continuous HFOV.
doi_str_mv 10.1542/peds.89.1.5
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_72749039</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A12029964</galeid><sourcerecordid>A12029964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c350t-eab895886c9192a3d8be18063fadf231b5c342b6a0f8881cd8f31a34f6e559523</originalsourceid><addsrcrecordid>eNpFkc1v1DAQxS1EVZbCiTOSD4gLZPFHnNjHasWXVKkc2rPl2OOtUWIHO1t1kfq_45IVnDyj9xtr3jyE3lCypaJln2ZwZSvVlm7FM7ShRMmmZb14jjaEcNq0hIgX6GUpPwkhrejZOTqnPZOE0Q16_JFTmcEu4R5wNtGlKfwGh22aZpNDSREnj-_C_q7xGX4dINojTsWGcTRLykdcRyoc7yEuIUUz4r9VFWuHQ8QZyhzyyrpQltoXXI7R5TTBK3TmzVjg9em9QLdfPt_svjVX11-_7y6vGssFWRowg1RCys4qqpjhTg5AJem4N84zTgdhecuGzhAvpaTWSc-p4a3vQAglGL9A79d_55yqh7LoKRQL1UOEdCi6Z32rCFcV_LiCezOCDrE6W-BhsWkcYQ-6LrW71peUEaZU11b8w4rbesWSwes5h8nko6ZEP2Wjn7LRUmmqRaXfnrY4DBO4_-waRtXfnXRTrBl9jcOG8g8TFekV5X8AGZ6agA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72749039</pqid></control><display><type>article</type><title>Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome</title><source>Elektronische Zeitschriftenbibliothek</source><creator>CLARK, R. H ; GERSTMANN, D. R ; NULL, D. M ; DELEMOS, R. A</creator><creatorcontrib>CLARK, R. H ; GERSTMANN, D. R ; NULL, D. M ; DELEMOS, R. A</creatorcontrib><description>A prospective randomized trial with a crossover design was conducted to compare the efficacy and safety of two distinct strategies of high-frequency oscillatory ventilation (HFOV) to conventional intermittent mandatory ventilation (CV) in the management of respiratory distress syndrome. Only premature neonates with a birth weight less than 1.751 kg were eligible for enrollment into the study. Of 83 patients studied, 26 patients were assigned to CV-only, 27 to HFOV for 72 hours followed by CV (HFOV/CV), and 30 to HFOV-only until extubation. There was no difference among the three groups with respect to the incidence of pulmonary airleak, intraventricular hemorrhage, or death. The highest incidence of chronic lung disease was in the CV-only group. Although both HFOV groups had a lower incidence of chronic lung disease assessed at 30 days and 36 weeks postconception age, the difference was statistically significant only between the CV-only and HFOV-only groups (65% vs 30% at 30 days; P = .008; 38% vs 10% at 36 weeks postconception age, P = .013). These results suggest that use of HFOV as the predominant mode of ventilation in the management of respiratory distress syndrome is as safe as CV and can contribute to a decreased incidence of chronic lung disease. Furthermore, a short (72-hour) period of HFOV support does not provide the same advantage as continuous HFOV.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.89.1.5</identifier><identifier>PMID: 1728021</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Analysis of Variance ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Artificial respiration ; Biological and medical sciences ; Bronchopulmonary dysplasia ; Care and treatment ; Emergency and intensive care: neonates and children. Prematurity. Sudden death ; Evaluation ; Female ; Humans ; Hyaline membrane disease ; Infant, Newborn ; Intensive care medicine ; Male ; Mechanical ventilation ; Medical sciences ; Prognosis ; Prospective Studies ; Pulmonary Gas Exchange ; Respiration, Artificial - adverse effects ; Respiration, Artificial - methods ; Respiratory Distress Syndrome, Newborn - physiopathology ; Respiratory Distress Syndrome, Newborn - therapy ; Ventilator Weaning</subject><ispartof>Pediatrics (Evanston), 1992, Vol.89 (1), p.5-12</ispartof><rights>1992 INIST-CNRS</rights><rights>COPYRIGHT 1992 American Academy of Pediatrics</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-eab895886c9192a3d8be18063fadf231b5c342b6a0f8881cd8f31a34f6e559523</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=5213791$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1728021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CLARK, R. H</creatorcontrib><creatorcontrib>GERSTMANN, D. R</creatorcontrib><creatorcontrib>NULL, D. M</creatorcontrib><creatorcontrib>DELEMOS, R. A</creatorcontrib><title>Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>A prospective randomized trial with a crossover design was conducted to compare the efficacy and safety of two distinct strategies of high-frequency oscillatory ventilation (HFOV) to conventional intermittent mandatory ventilation (CV) in the management of respiratory distress syndrome. Only premature neonates with a birth weight less than 1.751 kg were eligible for enrollment into the study. Of 83 patients studied, 26 patients were assigned to CV-only, 27 to HFOV for 72 hours followed by CV (HFOV/CV), and 30 to HFOV-only until extubation. There was no difference among the three groups with respect to the incidence of pulmonary airleak, intraventricular hemorrhage, or death. The highest incidence of chronic lung disease was in the CV-only group. Although both HFOV groups had a lower incidence of chronic lung disease assessed at 30 days and 36 weeks postconception age, the difference was statistically significant only between the CV-only and HFOV-only groups (65% vs 30% at 30 days; P = .008; 38% vs 10% at 36 weeks postconception age, P = .013). These results suggest that use of HFOV as the predominant mode of ventilation in the management of respiratory distress syndrome is as safe as CV and can contribute to a decreased incidence of chronic lung disease. Furthermore, a short (72-hour) period of HFOV support does not provide the same advantage as continuous HFOV.</description><subject>Analysis of Variance</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Artificial respiration</subject><subject>Biological and medical sciences</subject><subject>Bronchopulmonary dysplasia</subject><subject>Care and treatment</subject><subject>Emergency and intensive care: neonates and children. Prematurity. Sudden death</subject><subject>Evaluation</subject><subject>Female</subject><subject>Humans</subject><subject>Hyaline membrane disease</subject><subject>Infant, Newborn</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Mechanical ventilation</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Pulmonary Gas Exchange</subject><subject>Respiration, Artificial - adverse effects</subject><subject>Respiration, Artificial - methods</subject><subject>Respiratory Distress Syndrome, Newborn - physiopathology</subject><subject>Respiratory Distress Syndrome, Newborn - therapy</subject><subject>Ventilator Weaning</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNpFkc1v1DAQxS1EVZbCiTOSD4gLZPFHnNjHasWXVKkc2rPl2OOtUWIHO1t1kfq_45IVnDyj9xtr3jyE3lCypaJln2ZwZSvVlm7FM7ShRMmmZb14jjaEcNq0hIgX6GUpPwkhrejZOTqnPZOE0Q16_JFTmcEu4R5wNtGlKfwGh22aZpNDSREnj-_C_q7xGX4dINojTsWGcTRLykdcRyoc7yEuIUUz4r9VFWuHQ8QZyhzyyrpQltoXXI7R5TTBK3TmzVjg9em9QLdfPt_svjVX11-_7y6vGssFWRowg1RCys4qqpjhTg5AJem4N84zTgdhecuGzhAvpaTWSc-p4a3vQAglGL9A79d_55yqh7LoKRQL1UOEdCi6Z32rCFcV_LiCezOCDrE6W-BhsWkcYQ-6LrW71peUEaZU11b8w4rbesWSwes5h8nko6ZEP2Wjn7LRUmmqRaXfnrY4DBO4_-waRtXfnXRTrBl9jcOG8g8TFekV5X8AGZ6agA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>CLARK, R. H</creator><creator>GERSTMANN, D. R</creator><creator>NULL, D. M</creator><creator>DELEMOS, R. A</creator><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome</title><author>CLARK, R. H ; GERSTMANN, D. R ; NULL, D. M ; DELEMOS, R. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c350t-eab895886c9192a3d8be18063fadf231b5c342b6a0f8881cd8f31a34f6e559523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Analysis of Variance</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Artificial respiration</topic><topic>Biological and medical sciences</topic><topic>Bronchopulmonary dysplasia</topic><topic>Care and treatment</topic><topic>Emergency and intensive care: neonates and children. Prematurity. Sudden death</topic><topic>Evaluation</topic><topic>Female</topic><topic>Humans</topic><topic>Hyaline membrane disease</topic><topic>Infant, Newborn</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Mechanical ventilation</topic><topic>Medical sciences</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Pulmonary Gas Exchange</topic><topic>Respiration, Artificial - adverse effects</topic><topic>Respiration, Artificial - methods</topic><topic>Respiratory Distress Syndrome, Newborn - physiopathology</topic><topic>Respiratory Distress Syndrome, Newborn - therapy</topic><topic>Ventilator Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CLARK, R. H</creatorcontrib><creatorcontrib>GERSTMANN, D. R</creatorcontrib><creatorcontrib>NULL, D. M</creatorcontrib><creatorcontrib>DELEMOS, R. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CLARK, R. H</au><au>GERSTMANN, D. R</au><au>NULL, D. M</au><au>DELEMOS, R. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1992</date><risdate>1992</risdate><volume>89</volume><issue>1</issue><spage>5</spage><epage>12</epage><pages>5-12</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>A prospective randomized trial with a crossover design was conducted to compare the efficacy and safety of two distinct strategies of high-frequency oscillatory ventilation (HFOV) to conventional intermittent mandatory ventilation (CV) in the management of respiratory distress syndrome. Only premature neonates with a birth weight less than 1.751 kg were eligible for enrollment into the study. Of 83 patients studied, 26 patients were assigned to CV-only, 27 to HFOV for 72 hours followed by CV (HFOV/CV), and 30 to HFOV-only until extubation. There was no difference among the three groups with respect to the incidence of pulmonary airleak, intraventricular hemorrhage, or death. The highest incidence of chronic lung disease was in the CV-only group. Although both HFOV groups had a lower incidence of chronic lung disease assessed at 30 days and 36 weeks postconception age, the difference was statistically significant only between the CV-only and HFOV-only groups (65% vs 30% at 30 days; P = .008; 38% vs 10% at 36 weeks postconception age, P = .013). These results suggest that use of HFOV as the predominant mode of ventilation in the management of respiratory distress syndrome is as safe as CV and can contribute to a decreased incidence of chronic lung disease. Furthermore, a short (72-hour) period of HFOV support does not provide the same advantage as continuous HFOV.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>1728021</pmid><doi>10.1542/peds.89.1.5</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0031-4005
ispartof Pediatrics (Evanston), 1992, Vol.89 (1), p.5-12
issn 0031-4005
1098-4275
language eng
recordid cdi_proquest_miscellaneous_72749039
source Elektronische Zeitschriftenbibliothek
subjects Analysis of Variance
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Artificial respiration
Biological and medical sciences
Bronchopulmonary dysplasia
Care and treatment
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Evaluation
Female
Humans
Hyaline membrane disease
Infant, Newborn
Intensive care medicine
Male
Mechanical ventilation
Medical sciences
Prognosis
Prospective Studies
Pulmonary Gas Exchange
Respiration, Artificial - adverse effects
Respiration, Artificial - methods
Respiratory Distress Syndrome, Newborn - physiopathology
Respiratory Distress Syndrome, Newborn - therapy
Ventilator Weaning
title Prospective randomized comparison of high-frequency oscillatory and conventional ventilation in respiratory distress syndrome
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A47%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prospective%20randomized%20comparison%20of%20high-frequency%20oscillatory%20and%20conventional%20ventilation%20in%20respiratory%20distress%20syndrome&rft.jtitle=Pediatrics%20(Evanston)&rft.au=CLARK,%20R.%20H&rft.date=1992&rft.volume=89&rft.issue=1&rft.spage=5&rft.epage=12&rft.pages=5-12&rft.issn=0031-4005&rft.eissn=1098-4275&rft.coden=PEDIAU&rft_id=info:doi/10.1542/peds.89.1.5&rft_dat=%3Cgale_proqu%3EA12029964%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c350t-eab895886c9192a3d8be18063fadf231b5c342b6a0f8881cd8f31a34f6e559523%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=72749039&rft_id=info:pmid/1728021&rft_galeid=A12029964&rfr_iscdi=true