Multiparametric MRI ISODATA ischemic lesion Analysis: Correlation with the clinical neurological deficit and single-parameter MRI techniques

• Published in: Stroke (1970) 2002-12, Vol.33 (12), p.2839-2844
• Main Authors: MITSIAS, Panayiotis D, JACOBS, Michael A, HAMMOUD, Rabih, PASNOOR, Mamatha, SANTHAKUMAR, Sunitha, PAPAMITSAKIS, Nikolaos I. H, SOLTANIAN-ZADEH, Hamid, MEI LU, CHOPP, Michael, PATEL, Suresh C
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Algorithms; Biological and medical sciences; Brain - blood supply; Brain - pathology; Brain Ischemia - diagnosis; Brain Ischemia - pathology; Brain Ischemia - therapy; Contrast Media - administration & dosage; Diffusion Magnetic Resonance Imaging; Echo-Planar Imaging; Female; Gadolinium DTPA; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Neurology; Predictive Value of Tests; Registries; Severity of Illness Index; Time Factors; Treatment Outcome; Vascular diseases and vascular malformations of the nervous system
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/01.STR.0000043072.76353.7C

The purpose of this study was to show that the computer segmentation algorithm Iterative Self-Organizing Data Analysis Technique (ISODATA), which integrates multiple MRI parameters (diffusion-weighted imaging [DWI], T2-weighted imaging [T2WI], and T1-weighted imaging [T1WI]) into a single composite image, is capable of defining the ischemic lesion in a time-independent manner equally as well as the MRI techniques considered the best for each phase after stroke onset (ie, perfusion weighted imaging [PWI] and DWI for the acute phase and T2WI for the outcome phase). We measured MRI parameters of PWI, DWI, T2WI, and T1WI from patients at the acute phase (