Nosocomial transmission of Saccharomyces cerevisiae in bone marrow transplant patients

Saccharomyces cerevisiae is an unusual cause of clinical infection. We describe three bone marrow transplant patients on a haematology unit who developed possible invasive disease with the organism. Two patients died and both these patients appeared to have a related strain of S. cerevisiae. Screeni...

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Bibliographic Details
Published in:The Journal of hospital infection 2002-12, Vol.52 (4), p.268-272
Main Authors: Olver, W.J., James, S.A., Lennard, A., Galloway, A., Roberts, I.N., Boswell, T.C., Russell, N.H.
Format: Article
Language:English
Subjects:
Adult
Amphotericin B - therapeutic use
Antifungal Agents - therapeutic use
Biological and medical sciences
Bone Marrow Transplantation - adverse effects
Carrier State - transmission
Cross Infection - drug therapy
Cross Infection - etiology
Cross Infection - transmission
DNA, Fungal - analysis
Drug Therapy, Combination
Fatal Outcome
Feces - microbiology
Female
Flucytosine - therapeutic use
Genotype
Human mycoses
Humans
Immunocompromised Host
Infection Control
Infectious diseases
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy
Male
Mass Screening
Medical sciences
Miscellaneous mycoses
Multiple Organ Failure - microbiology
Mycoses
Mycoses - drug therapy
Mycoses - etiology
Mycoses - transmission
Pharynx - microbiology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae, nosocomial transmission, bone marrow transplantation
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Summary:Saccharomyces cerevisiae is an unusual cause of clinical infection. We describe three bone marrow transplant patients on a haematology unit who developed possible invasive disease with the organism. Two patients died and both these patients appeared to have a related strain of S. cerevisiae. Screening for S. cerevisiae from throat and stool samples revealed four further patients who were carriers. Genotyping of the invasive and carriage strains demonstrated an indistinguishable strain from patients who had been on the unit at the same time, suggesting cross-infection.
ISSN:0195-6701
1532-2939
DOI:10.1053/jhin.2002.1314