The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus

Several clinical series, analyzing fracture healing in patients with diabetes mellitus (DM), demonstrated significant incidence of delayed union, non-union, and pseudarthrosis. In this study, analysis was performed to evaluate the effects of blood glucose (BG) control on fracture healing in the DM B...

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Bibliographic Details
Published in:Journal of orthopaedic research 2002-11, Vol.20 (6), p.1210-1216
Main Authors: Beam, Heather A, Russell Parsons, J, Lin, Sheldon S
Format: Article
Language:English
Subjects:
Animals
BB Wistar rat
Biomechanical Phenomena
Blood Glucose - metabolism
Bromodeoxyuridine - metabolism
Cell Division
Diabetes mellitus
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - drug therapy
Disease Models, Animal
Femoral Fractures - complications
Femoral Fractures - pathology
Femoral Fractures - physiopathology
Fracture
Fracture Healing
Hypoglycemic Agents - pharmacology
Insulin
Insulin - pharmacology
Male
Microscopy, Acoustic
Rats
Rats, Inbred BB
Rats, Wistar
Torque
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Summary:Several clinical series, analyzing fracture healing in patients with diabetes mellitus (DM), demonstrated significant incidence of delayed union, non-union, and pseudarthrosis. In this study, analysis was performed to evaluate the effects of blood glucose (BG) control on fracture healing in the DM BB Wistar rat, a rat strain that represents a close homology to Type I DM in man. Our study showed decreased cell proliferation at the fracture site as well as decreased mechanical stiffness and bony content in the poorly controlled DM rats. To determine the effect of BG control, DM rats were treated with insulin sufficient to maintain physiologic BG levels throughout the course of the study. Values of cellular proliferation, biomechanical properties and callus bone content in tightly controlled DM animals were not significantly different from values of non-DM control values. This study suggests that insulin treatment with resultant improved BG control will ameliorate the impaired early and late parameters of DM fracture healing.
ISSN:0736-0266
1554-527X
DOI:10.1016/S0736-0266(02)00066-9